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Compare Thiothixene vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Thiothixene (Navane) and olanzapine (Zyprexa) are both antipsychotic medications, but they belong to different classes and have distinct differences. Thiothixene is a first-generation (typical) antipsychotic used to treat schizophrenia in people 12 years and older. It works by lowering dopamine levels in the brain and is known to cause more uncontrolled muscle movements compared to some other antipsychotics. On the other hand, olanzapine is an atypical antipsychotic used to treat schizophrenia and bipolar disorder in people 13 years and older, and it can also be used for certain types of depression when combined with fluoxetine (Prozac). Olanzapine affects both dopamine and serotonin levels and is more likely to cause weight gain and metabolic issues like high blood sugar and cholesterol. Thiothixene is typically taken multiple times a day, while olanzapine is usually taken once daily. Both medications can cause drowsiness and have serious side effects, but olanzapine is also available as an injection for acute agitation, which is not an option for thiothixene.

  • Thiothixene
    Olanzapine (Zyprexa)
  • Thiothixene
    Olanzapine (Zyprexa)

  • Summary of Thiothixene vs. Zyprexa

    Summary for First-generation (typical) antipsychotic
    Prescription only

    Thiothixene is used to treat schizophrenia in people ages 12 years and older. It belongs to a drug class known as typical antipsychotics. This medication comes as a oral capsule and it's typically taken 2-3 times a day. Some of the more common side effects of this medication include drowsiness, restlessness, and uncontrolled body movement. Thiothixene is only available as a generic medication. Brand name Navane has been discontinued.

    Summary for Atypical antipsychotic
    Prescription only

    Olanzapine (Zyprexa) is an atypical antipsychotic used treat schizophrenia or bipolar disorder. It can also treat depression, in combination with fluoxetine (Prozac), when other treatments haven't worked well. This medication is thought to work by balancing the levels of certain chemicals in the brain. Olanzapine (Zyprexa) is taken by mouth, typically once daily, by adults and children. Olanzapine (Zyprexa) is also available as an injection that's usually given in a hospital or clinic setting. Some of the more common side effects of olanzapine (Zyprexa) include sleep problems, dizziness, and weight gain.

  • Indications of Thiothixene vs. Zyprexa

    Indications for
    •Schizophrenia in people ages 12 years and older
    Indications for
    •Schizophrenia in adults and children age 13 years and older
    •Bipolar I disorder in adults and children age 13 years and older

    When taken with fluoxetine (Prozac):

    •Bipolar depression in adults and children age 10 years and older
    •Depression that hasn't responded well to other treatments

  • Pros and Cons of Thiothixene vs. Zyprexa

    Pros and Const for First-generation (typical) antipsychotic
    Pros
    •Taken by mouth
    •Can be taken by children as young as 12 years old
    •Dose can be adjusted based on your response
    Cons
    •Might need to take up to 3 times a day
    •Can cause low white blood cell counts so might need to have regular blood tests done
    •More likely to cause movement-related problems than atypical antipsychotics
    Pros and Const for Atypical antipsychotic
    Pros
    •Taken by mouth
    •Taken once daily
    •Might notice an improvement in your symptoms in as early as a week of starting olanzapine (Zyprexa)
    •Available as a lower-cost generic
    Cons
    •Can cause anticholinergic side effects, such as constipation and dry mouth
    •Can affect your sleep
    •More likely to cause weight gain, high blood cholesterol, and high blood sugar levels compared to some other atypical antipsychotics

  • Common Side Effects of Thiothixene vs. Zyprexa

    Common Side Effects for
    •Drowsiness
    •Trouble sleeping
    •Restlessness
    •Uncontrollable body movement
    Common Side Effects for
    •Sleepiness (29%)
    •Trouble sleeping (12%)
    •Accidental injury (12%)
    •Dizziness (11%)
    •Weakness (10%)
    •Dry mouth (9%)
    •Constipation (9%)
    •Upset stomach (7%)
    •Runny nose (7%)

  • Warnings of Thiothixene vs. Zyprexa

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Abnormal and prolonged muscle contractions (dystonia)
    •Neuroleptic malignant syndrome (NMS)
    •Seizures
    •Drowsiness and sleepiness
    •Low white blood cell count
    •Vision changes
    •High prolactin levels
    Common Side Effects for
    •Higher risk of death in older people with dementia-related psychosis
    •Worsening depression, suicidal thoughts and behavior
    •Severe allergic skin reactions
    •Neuroleptic malignant syndrome
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •Difficulty controlling body movements
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Seizures
    •High prolactin levels
    •Difficulty concentrating and extreme sleepiness
    •Anticholinergic side effects

  • Prices with our coupons for Thiothixene vs. Zyprexa

    Learn more about Thiothixene
    Learn more about Olanzapine

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