Key takeaways
Thiothixene (Navane) and clozapine (Clozaril) are both used to treat schizophrenia, but they have some key differences. Thiothixene is a first-generation (typical) antipsychotic, while clozapine is a second-generation (atypical) antipsychotic. Thiothixene works by lowering dopamine levels in the brain and is known to cause more uncontrolled muscle movements compared to other antipsychotics. On the other hand, clozapine affects both dopamine and serotonin activity and is not a first-choice medication due to its many side effects, including a dangerously low white blood cell count. Clozapine requires regular blood tests under a special program called REMS to monitor white blood cell levels, while thiothixene does not have such a requirement. Additionally, clozapine can cause weight gain, high blood sugar, and high cholesterol, whereas thiothixene is less likely to cause dry mouth, constipation, and blurred vision. Both medications can cause drowsiness and should not be stopped abruptly without consulting your healthcare provider.
