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Compare Fluphenazine vs. Thiothixene

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Fluphenazine (generic, formerly known as Prolixin) and Thiothixene (generic, formerly known as Navane) are both typical antipsychotics, but they have some differences. Fluphenazine is used to treat psychotic disorders and is available in both short-acting and long-acting forms, which can be taken orally or via injection. Thiothixene, on the other hand, is used specifically for schizophrenia and is only available in oral form. Fluphenazine is typically taken multiple times a day, while Thiothixene's dosing can vary based on the severity of symptoms, sometimes requiring multiple doses per day as well. Both medications can cause movement problems, including uncontrolled muscle movements. Additionally, Thiothixene is less likely to cause anticholinergic side effects like dry mouth and constipation compared to some other antipsychotics. Both medications should be used with caution in older adults with dementia-related psychosis due to an increased risk of death.

  • Fluphenazine
    Thiothixene
  • Fluphenazine
    Thiothixene

  • Summary of Fluphenazine vs. Thiothixene

    Summary for Typical antipsychotic
    Prescription only

    Fluphenazine is a typical antipsychotic and is used to treat conditions that cause psychosis. It's available as short-acting fluphenazine hydrochloride (tablets, liquid, injection) that's typically taken by mouth or injected 3 to 4 times a day. It also comes as long-acting fluphenazine decanoate (injection) that's usually given every 4 to 6 weeks. Side effects of this medication include drowsiness and movement problems. Brand name Prolixin is no longer available.

    Summary for First-generation (typical) antipsychotic
    Prescription only

    Thiothixene is used to treat schizophrenia in people ages 12 years and older. It belongs to a drug class known as typical antipsychotics. This medication comes as a oral capsule and it's typically taken 2-3 times a day. Some of the more common side effects of this medication include drowsiness, restlessness, and uncontrolled body movement. Thiothixene is only available as a generic medication. Brand name Navane has been discontinued.

  • Indications of Fluphenazine vs. Thiothixene

    Indications for
    •Psychotic disorders
    Indications for
    •Schizophrenia in people ages 12 years and older

  • Pros and Cons of Fluphenazine vs. Thiothixene

    Pros and Const for Typical antipsychotic
    Pros
    •Available as a lower-cost generic medication
    •Comes as a tablet, liquid, or injection (both short- and long-acting)
    •Dose can be easily adjusted based on individual needs
    Cons
    •Long-term use can raise the risk of permanent movement problems
    •Not safe for use in older adults with dementia-related psychosis
    •Might not be a safe option if you've had a bad reaction to similar medications (e.g., chlorpromazine (Thorazine), thioridazine (Mellaril))
    Pros and Const for First-generation (typical) antipsychotic
    Pros
    •Taken by mouth
    •Can be taken by children as young as 12 years old
    •Dose can be adjusted based on your response
    Cons
    •Might need to take up to 3 times a day
    •Can cause low white blood cell counts so might need to have regular blood tests done
    •More likely to cause movement-related problems than atypical antipsychotics

  • Common Side Effects of Fluphenazine vs. Thiothixene

    Common Side Effects for
    •Dystonia (uncontrollable muscle contractions): neck spasms, difficulty swallowing and breathing, sticking your tongue out
    •Involuntary movements (especially of the face or mouth)
    •Changes in blood pressure
    •Weight changes
    •Fluid retention (holding onto fluid)
    •Nausea
    •Constipation
    •Loss of appetite
    •Dry mouth
    •Headache
    •Salivation, drooling
    •More sweating
    •Frequent urination
    Common Side Effects for
    •Drowsiness
    •Trouble sleeping
    •Restlessness
    •Uncontrollable body movement

  • Warnings of Fluphenazine vs. Thiothixene

    Common Side Effects for
    •Higher risk of death in older people with dementia-related psychosis
    •Difficulty controlling movements
    •Neuroleptic malignant syndrome
    •Low white blood cell counts
    •High prolactin levels
    •Harm to unborn babies
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Abnormal and prolonged muscle contractions (dystonia)
    •Neuroleptic malignant syndrome (NMS)
    •Seizures
    •Drowsiness and sleepiness
    •Low white blood cell count
    •Vision changes
    •High prolactin levels

  • Prices with our coupons for Fluphenazine vs. Thiothixene

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