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Compare Geodon vs. Invega

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ziprasidone (Geodon) and paliperidone (Invega) are both atypical antipsychotics, but they have some key differences. Ziprasidone is used to treat bipolar I disorder and schizophrenia, while paliperidone is used for schizophrenia and schizoaffective disorder. Ziprasidone is taken twice daily with food, whereas paliperidone is an extended-release tablet taken once daily, with or without food. Ziprasidone is available in both oral and injectable forms, while paliperidone is available as an oral tablet and in long-acting injectable forms. Common side effects of ziprasidone include sleepiness and nausea, while paliperidone often causes drowsiness and abnormal muscle movements. Both medications can cause weight gain, but ziprasidone is less likely to do so compared to other antipsychotics. Additionally, paliperidone can lead to higher prolactin levels, which may cause sexual dysfunction and other hormonal issues.

  • Ziprasidone (Geodon)
    Invega (paliperidone)
  • Ziprasidone (Geodon)
    Invega (paliperidone)

  • Summary of Geodon vs. Invega

    Summary for Atypical antipsychotic
    Prescription only

    Ziprasidone (Geodon) is an atypical antipsychotic medication used to treat bipolar I disorder and schizophrenia in adults. It works by balancing the levels of certain chemicals in the brain, like dopamine and serotonin. Ziprasidone (Geodon) is taken by mouth, typically twice daily. It's also available as an injection that's given into the muscles by a healthcare provider to treat agitation in schizophrenia. Some common side effects of ziprasidone (Geodon) include uncontrolled body movements, sleepiness, and nausea.

    Summary for Atypical antipsychotic
    Prescription only

    Invega (paliperidone) is taken by mouth and used to improve mood, thoughts, and behaviors in people who have schizophrenia or schizoaffective disorder. It's available as both brand and generic versions in an extended-release pill, which means the medication is released slowly in your body. It only needs to be taken once a day. Some common side effects include drowsiness and uncontrolled muscle movements. There are long-acting injection forms of this medication available given by a trained healthcare provider.

  • Indications of Geodon vs. Invega

    Indications for
    •Bipolar I disorder
    •Schizophrenia
    Indications for
    •Schizophrenia
    •Schizoaffective disorder

  • Pros and Cons of Geodon vs. Invega

    Pros and Const for Atypical antipsychotic
    Pros
    •Taken by mouth
    •Less likely to weight gain than other similar medications
    •Available as a lower-cost generic medication
    Cons
    •Taken twice daily
    •Might take several weeks before you feel the full benefits of this medication
    •Must be taken with food
    Pros and Const for Atypical antipsychotic
    Pros
    •Available in many different strengths to make it easier to customize your dose
    •Can be used in adolescents
    •Only need to take the medication once a day
    Cons
    •You might have to see your provider several times until you find a dose that works best for you
    •Can make you feel sleepy or sedated
    •Can cause weight gain

  • Common Side Effects of Geodon vs. Invega

    Common Side Effects for
    •Uncontrolled body movements (14%)
    •Sleepiness (14%)
    •Nausea (10%)
    •Constipation (9%)
    •Indigestion (8%)
    •Restlessness (8%)
    •Dizziness (8%)
    •Respiratory tract infection (8%)

    Note: Side effects listed were reported by people who took ziprasidone for schizophrenia in a clinical study

    Common Side Effects for
    •Abnormal muscle movements (up to 40%)
    •Drowsiness (up to 26%)
    •Headache (up to 14%)
    •Irregular heart beat (up to 14%)
    •Vomiting (up to 11%)
    •Anxiety (up to 9%)

  • Warnings of Geodon vs. Invega

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Risk of suicidal thoughts and behavior
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •Neuroleptic malignant syndrome
    •Difficulty concentrating and extreme sleepiness
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Seizures
    •Serious skin reaction
    •Prolonged and painful erection
    •High prolactin levels
    •Heart rhythm problems
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome (NMS)
    •High blood sugar, high cholesterol, and weight gain
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Higher risk of falls
    •High prolactin levels
    •Higher risk of infections
    •Not for people with gut problems
    •Heart rhythm problem (QT prolongation)

  • Prices with our coupons for Geodon vs. Invega

    Learn more about Ziprasidone
    Learn more about Invega

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