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Compare Geodon vs. Fanapt

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ziprasidone (Geodon) and iloperidone (Fanapt) are both atypical antipsychotics used to treat schizophrenia, but they have some key differences. Ziprasidone is also approved for treating bipolar I disorder, while iloperidone is not. Ziprasidone is available in both generic and brand forms, making it more affordable, whereas iloperidone is only available as a brand name (Fanapt), which can be more expensive. Ziprasidone must be taken with food twice daily, while iloperidone also requires twice-daily dosing but does not specify the need to be taken with food. Both medications can cause sleepiness and weight gain, but ziprasidone is less likely to cause weight gain compared to other antipsychotics. Additionally, ziprasidone is available as an injection for treating agitation in schizophrenia, which iloperidone does not offer. Both medications carry risks of serious side effects, including neuroleptic malignant syndrome and tardive dyskinesia, but they also have unique risks, such as heart rhythm problems with ziprasidone and difficulty controlling body temperature with iloperidone.

  • Ziprasidone (Geodon)
    Iloperidone (Fanapt)
  • Ziprasidone (Geodon)
    Iloperidone (Fanapt)

  • Summary of Geodon vs. Fanapt

    Summary for Atypical antipsychotic
    Prescription only

    Ziprasidone (Geodon) is an atypical antipsychotic medication used to treat bipolar I disorder and schizophrenia in adults. It works by balancing the levels of certain chemicals in the brain, like dopamine and serotonin. Ziprasidone (Geodon) is taken by mouth, typically twice daily. It's also available as an injection that's given into the muscles by a healthcare provider to treat agitation in schizophrenia. Some common side effects of ziprasidone (Geodon) include uncontrolled body movements, sleepiness, and nausea.

    Summary for Second Generation (Atypical) Antipsychotic
    Prescription only

    Iloperidone (Fanapt) is an atypical antipsychotic. Brand name Fanapt is FDA-approved for schizophrenia and bipolar disorder in adults. Generic iloperidone is currently only approved for schizophrenia. Iloperidone (Fanapt) comes as a tablet that's taken by mouth twice per day. Don't drink alcohol while taking iloperidone (Fanapt) because doing so can worsen some common side effects, like sleepiness and dizziness. Some people have reported weight gain while taking this medication.

  • Indications of Geodon vs. Fanapt

    Indications for
    •Bipolar I disorder
    •Schizophrenia
    Indications for
    •Schizophrenia in adults
    •Manic or mixed episodes of bipolar I disorder in adults (brand name Fanapt only)

  • Pros and Cons of Geodon vs. Fanapt

    Pros and Const for Atypical antipsychotic
    Pros
    •Taken by mouth
    •Less likely to weight gain than other similar medications
    •Available as a lower-cost generic medication
    Cons
    •Taken twice daily
    •Might take several weeks before you feel the full benefits of this medication
    •Must be taken with food
    Pros and Const for Second Generation (Atypical) Antipsychotic
    Pros
    •Taken by mouth
    •Comes in many different strengths to make it easier to customize your dose
    •A starter pack is available for when you first start to help you figure out your dose.
    •Available as a lower-cost generic
    Cons
    •Taken twice a day
    •Hasn't been studied in children
    •The dose needs to be slowly raised
    •Safety in pregnancy and breastfeeding isn't well-understood

  • Common Side Effects of Geodon vs. Fanapt

    Common Side Effects for
    •Uncontrolled body movements (14%)
    •Sleepiness (14%)
    •Nausea (10%)
    •Constipation (9%)
    •Indigestion (8%)
    •Restlessness (8%)
    •Dizziness (8%)
    •Respiratory tract infection (8%)

    Note: Side effects listed were reported by people who took ziprasidone for schizophrenia in a clinical study

    Common Side Effects for

    Schizophrenia

    •Dizziness (up to 20%)
    •Sleepiness (up to 15%)
    •Fast heart rate (up to 12%)
    •Dry mouth (up to 10%)
    •Nausea (up to 10%)

    Bipolar disorder

    •Fast heart rate (up to 23%)
    •Dizziness (up to 12%)

  • Warnings of Geodon vs. Fanapt

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Risk of suicidal thoughts and behavior
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •Neuroleptic malignant syndrome
    •Difficulty concentrating and extreme sleepiness
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Seizures
    •Serious skin reaction
    •Prolonged and painful erection
    •High prolactin levels
    •Heart rhythm problems
    Common Side Effects for
    •Higher risk of death in older people with dementia-related psychosis
    •Life-threatening abnormal heart rhythm (QT prolongation)
    •Neuroleptic malignant syndrome
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •Difficulty controlling body movements
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Seizures
    •High prolactin levels
    •Difficulty concentrating and extreme sleepiness
    •Prolonged and painful erection
    •Intraoperative floppy iris syndrome (IFIS)

  • Prices with our coupons for Geodon vs. Fanapt

    Learn more about Ziprasidone
    Learn more about Iloperidone

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