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Compare Invega vs. Seroquel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Invega (paliperidone) and Seroquel (quetiapine) are both atypical antipsychotics, but they have some key differences. Invega is used to treat schizophrenia and schizoaffective disorder, while Seroquel is used for schizophrenia, bipolar disorder, and as an add-on for depression. Invega is available as an extended-release tablet taken once daily, whereas Seroquel comes in both immediate-release and extended-release forms, with the immediate-release needing to be taken 2 to 3 times a day. Invega can cause side effects like drowsiness and uncontrolled muscle movements, while Seroquel is more likely to cause weight gain, high blood sugar, and high cholesterol. Both medications can cause serious side effects like neuroleptic malignant syndrome and QT prolongation, but Seroquel also carries a risk of worsening depression and suicidal thoughts, especially in younger people. Additionally, Invega is not recommended for older adults with dementia-related psychosis due to a higher risk of death, a warning that also applies to Seroquel.

Invega (paliperidone)
Quetiapine (Seroquel)
Invega (paliperidone)
Quetiapine (Seroquel)
Summary of Invega vs. Seroquel
Summary for Atypical antipsychotic
Prescription only
Invega (paliperidone) is taken by mouth and used to improve mood, thoughts, and behaviors in people who have schizophrenia or schizoaffective disorder. It's available as both brand and generic versions in an extended-release pill, which means the medication is released slowly in your body. It only needs to be taken once a day. Some common side effects include drowsiness and uncontrolled muscle movements. There are long-acting injection forms of this medication available given by a trained healthcare provider.
Summary for Atypical antipsychotic
Prescription only
Quetiapine (Seroquel) is an atypical antipsychotic. It's used to treat mental health problems like schizophrenia and bipolar disorder. This medication comes as an immediate-release tablet (Seroquel) that's taken by mouth usually twice a day. There's also an extended-release tablet (Seroquel XR) that's taken once a day. The specific dosage depends on how well it's helping your mood, thoughts, and behaviors. Side effects can include sleepiness, headache, and possible weight gain. There are brand-name and generic versions of this medication.
Indications of Invega vs. Seroquel
Indications for

•Schizophrenia

•Schizoaffective disorder

Indications for

•Schizophrenia in adults and children ages 13 years and older

•Bipolar disorder in adults and certain children ages 10 years and older

•Depression in adults, as an add-on to other antidepressants - extended-release only
Pros and Cons of Invega vs. Seroquel
Pros and Const for Atypical antipsychotic
Pros

•Available in many different strengths to make it easier to customize your dose

•Can be used in adolescents

•Only need to take the medication once a day

Cons

•You might have to see your provider several times until you find a dose that works best for you

•Can make you feel sleepy or sedated

•Can cause weight gain

Pros and Const for Atypical antipsychotic
Pros

•Taken by mouth

•Might notice an improvement in your symptoms in as early as a week of starting the medication

•Available in both short-acting and long-acting tablets

Cons

•Might cause weight gain

•Can raise your blood sugar and cholesterol levels

•Not recommended for older adults who have dementia-related psychosis
Common Side Effects of Invega vs. Seroquel
Common Side Effects for

•Abnormal muscle movements (up to 40%)

•Drowsiness (up to 26%)

•Headache (up to 14%)

•Irregular heart beat (up to 14%)

•Vomiting (up to 11%)

•Anxiety (up to 9%)

Common Side Effects for
Immediate-release tablets:

•Headache (21%)

•Agitation (20%)

•Sleepiness (18%)

•Dizziness (11%)

•Dry mouth (9%)

•Constipation (8%)

•Pain (7%)

•Fast heart rate (6%)

•Vomiting (6%)

Extended-release tablets:

•Sleepiness (25%)

•Dry mouth (12%)

•Dizziness (10%)

•Trouble controlling muscle movements (8%)

•Low blood pressure when standing up (7%)

•Constipation (6%)
Warnings of Invega vs. Seroquel
Common Side Effects for

•Higher risk of death in older adults with dementia-related psychosis

•Neuroleptic malignant syndrome (NMS)

•High blood sugar, high cholesterol, and weight gain

•Difficulty controlling muscle movements (tardive dyskinesia)

•Higher risk of falls

•High prolactin levels

•Higher risk of infections

•Not for people with gut problems

•Heart rhythm problem (QT prolongation)

Common Side Effects for

•Higher risk of death and stroke in older people with dementia-related psychosis

•Risk of suicidal thoughts and behavior

•Neuroleptic malignant syndrome

•High blood sugar, high cholesterol, and weight gain

•Trouble controlling muscle movements (tardive dyskinesia)

•Changes in blood pressure

•Risk of falls

•Risk of infection (due to low white blood cell counts)

•Possible changes in heart rhythm

•Seizures

•Hypothyroidism (low thyroid hormone)

•High prolactin levels

•Feeling very sleepy and having trouble concentrating
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Compare Invega vs. Seroquel

Key takeaways

Summary of Invega vs. Seroquel

Indications of Invega vs. Seroquel

Pros and Cons of Invega vs. Seroquel

Common Side Effects of Invega vs. Seroquel

Warnings of Invega vs. Seroquel

Prices with our coupons for Invega vs. Seroquel

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