Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Haldol (haloperidol) and Invega (paliperidone) are both antipsychotic medications used to treat schizophrenia, but they have some key differences. Haldol is a typical antipsychotic that works by blocking dopamine activity in the brain and is available in oral forms, as well as an injection, either long-acting or short-acting. In contrast, Invega is an atypical antipsychotic that affects both dopamine and serotonin levels and is taken orally as an extended-release tablet. Haldol long-acting injection is typically given monthly by a healthcare provider, and Invega is also available as a long-acting injection. Both medications can cause movement-related side effects, such as rigid muscles and tremors, as well as weight gain and high blood sugar levels. However, Haldol may be less likely to cause weight gain compared to Invega. Both medications should not be used in older adults with dementia-related psychosis due to an increased risk of death.
Haloperidol injection
Invega (paliperidone)
Haloperidol injection
Invega (paliperidone)
Summary of Haldol vs. Invega
Summary for Typical antipsychotic
Prescription only
Haloperidol injection is an antipsychotic medication that's used to treat schizophrenia. It's a long-acting injection that's given into the muscles monthly by a healthcare provider. It's also available as a shorter-acting injection that's typically given in a hospital setting to people who are experiencing agitation related to schizophrenia. The most common side effects of haloperidol injection are movement-related side effects, such as rigid muscles, tremors, and trouble speaking.
Summary for Atypical antipsychotic
Prescription only
Invega (paliperidone) is taken by mouth and used to improve mood, thoughts, and behaviors in people who have schizophrenia or schizoaffective disorder. It's available as both brand and generic versions in an extended-release pill, which means the medication is released slowly in your body. It only needs to be taken once a day. Some common side effects include drowsiness and uncontrolled muscle movements. There are long-acting injection forms of this medication available given by a trained healthcare provider.
Indications of Haldol vs. Invega
Indications for
•Schizophrenia
Indications for
•Schizophrenia
•Schizoaffective disorder
Pros and Cons of Haldol vs. Invega
Pros and Const for Typical antipsychotic
Pros
•Typically given monthly
•Low risk for weight gain, compared to some other antipsychotics