Key takeaways
Haldol (haloperidol) and Rexulti (brexpiprazole) are both antipsychotic medications, but they belong to different classes and have distinct uses and side effects. Haldol is a typical antipsychotic used mainly to treat schizophrenia and is available as oral forms, and an injection, either long-acting or short-acting. Rexulti, on the other hand, is an atypical antipsychotic that treats schizophrenia, depression (as an add-on), and dementia-related agitation from Alzheimer's disease, and it is taken orally once a day. Haldol works by blocking dopamine activity in the brain, while Rexulti balances both dopamine and serotonin, which helps improve mood and behavior. Haldol is available as a lower-cost generic, while Rexulti is only available as a brand-name medication, making it potentially more expensive. Additionally, Haldol has a higher risk of movement-related side effects, whereas Rexulti is less likely to cause these issues but may lead to impulsive behaviors and higher blood sugar levels.
