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Compare Haldol vs. Rexulti

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Haldol (haloperidol) and Rexulti (brexpiprazole) are both antipsychotic medications, but they belong to different classes and have distinct uses and side effects. Haldol is a typical antipsychotic used mainly to treat schizophrenia and is available as oral forms, and an injection, either long-acting or short-acting. Rexulti, on the other hand, is an atypical antipsychotic that treats schizophrenia, depression (as an add-on), and dementia-related agitation from Alzheimer's disease, and it is taken orally once a day. Haldol works by blocking dopamine activity in the brain, while Rexulti balances both dopamine and serotonin, which helps improve mood and behavior. Haldol is available as a lower-cost generic, while Rexulti is only available as a brand-name medication, making it potentially more expensive. Additionally, Haldol has a higher risk of movement-related side effects, whereas Rexulti is less likely to cause these issues but may lead to impulsive behaviors and higher blood sugar levels.

  • Haloperidol injection
    Rexulti (brexpiprazole)
  • Haloperidol injection
    Rexulti (brexpiprazole)

  • Summary of Haldol vs. Rexulti

    Summary for Typical antipsychotic
    Prescription only

    Haloperidol injection is an antipsychotic medication that's used to treat schizophrenia. It's a long-acting injection that's given into the muscles monthly by a healthcare provider. It's also available as a shorter-acting injection that's typically given in a hospital setting to people who are experiencing agitation related to schizophrenia. The most common side effects of haloperidol injection are movement-related side effects, such as rigid muscles, tremors, and trouble speaking.

    Summary for Atypical antipsychotic
    Prescription only

    Rexulti (brexpiprazole) is an atypical antipsychotic used to treat depression and schizophrenia. It can also help manage dementia-related agitation from Alzheimer's disease. The medication works by balancing chemicals in your brain to regulate your mood. Rexulti (brexpiprazole) comes as a tablet you take by mouth, usually once a day. Common side effects include weight gain, sleepiness, and dizziness. Although generic versions have been approved, they aren't yet available in pharmacies.

  • Indications of Haldol vs. Rexulti

    Indications for
    •Schizophrenia
    Indications for
    •Add-on treatment for depression in adults
    •Schizophrenia in adults and teens 13 years and older
    •Dementia-related agitation from Alzheimer's disease

  • Pros and Cons of Haldol vs. Rexulti

    Pros and Const for Typical antipsychotic
    Pros
    •Typically given monthly
    •Low risk for weight gain, compared to some other antipsychotics
    •Available as a lower-cost, generic medication
    Cons
    •Needs to be injected
    •Higher risk of movement-related side effects compared to atypical antipsychotics
    •Can't be used in children
    Pros and Const for Atypical antipsychotic
    Pros
    •Only need to take once a day
    •Less likely to cause weight gain compared to older antipsychotics
    •Available in many strengths
    Cons
    •Can take a couple of months to fully work
    •Interacts with many medications
    •Not known if safe in pregnancy

  • Common Side Effects of Haldol vs. Rexulti

    Common Side Effects for
    •Stiff or rigid muscles, tremors, trouble speaking, and other parkinsonism symptoms (31%)
    Common Side Effects for

    Depression

    •Fidgeting (9%)
    •Weight gain (7%)
    •Headache (7%)
    •Sleepiness (5%)

    Schizophrenia

    •Fidgeting (6%)

    Dementia-related agitation

    •Headache (8%)

  • Warnings of Haldol vs. Rexulti

    Common Side Effects for
    •Higher risk of death in older people with dementia-related psychosis
    •Life-threatening abnormal heart rhythm (QT prolongation)
    •Difficulty controlling body movements
    •Neuroleptic malignant syndrome (NMS)
    •Higher risk of falls
    •Pneumonia
    •Low white blood cell counts
    •Harm to unborn babies
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Suicidal thoughts and behaviors
    •Neuroleptic malignant syndrome (NMS)
    •Uncontrolled body movements (tardive dyskinesia)
    •High blood sugar, high cholesterol, and weight gain
    •Impulse control problems
    •Low white blood cell count
    •Falls and fainting
    •Seizures
    •Trouble controlling body temperature
    •Difficulty swallowing
    •Problems with thinking and movement

  • Prices with our coupons for Haldol vs. Rexulti

    Learn more about Haloperidol injection
    Learn more about Rexulti

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