Key takeaways
Haloperidol (Haldol) and thioridazine (Mellaril) are both typical antipsychotics used to treat schizophrenia, but they have some key differences. Haloperidol is available as an oral tablet, oral liquid, and injection, while thioridazine is taken orally multiple times a day. Haloperidol is often used as a first-choice treatment, whereas thioridazine is reserved for cases where other antipsychotics haven't worked or caused intolerable side effects. Both medications can cause dangerous heart rhythm changes (QTc prolongation). Both medications can cause serious side effects like neuroleptic malignant syndrome and should not be used in older adults with dementia-related psychosis.
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