provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Haloperidol Decanoate Coupon - Haloperidol Decanoate 1ml of 100mg/ml vial

haloperidol injection

Generic Haldol
Used for Bipolar Disorder, Schizophrenia, Tourette Syndrome
Used for Bipolar Disorder, Schizophrenia, Tourette Syndrome

Haloperidol injection is an antipsychotic medication that's used to treat schizophrenia. It's a long-acting injection that's given into the muscles monthly by a healthcare provider. It's also available as a shorter-acting injection that's typically given in a hospital setting to people who are experiencing agitation related to schizophrenia. The most common side effects of haloperidol injection are movement-related side effects, such as rigid muscles, tremors, and trouble speaking.

Last reviewed on May 8, 2023
basics-icon

What is Haloperidol injection?

What is Haloperidol injection used for?

  • Schizophrenia

How Haloperidol injection works

Haloperidol injection is a typical antipsychotic. It works by blocking the activity of dopamine, a chemical involved with mood and movement, in your brain. This leads to lower dopamine levels, which causes less hallucinations (seeing things that aren't there) and delusions (beliefs in things that aren't true).

Are you looking for information on oral haloperidol instead?

Drug Facts

Common BrandsHaldol
Drug ClassTypical antipsychotic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
coupon-save-icon

Get your GoodRx coupon

Avg retail price
$61.01(save 77.12%)
GoodRx discount
$13.96
See prices
basics-icon

What are the side effects of Haloperidol injection?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Spasms in muscles of the eye
  • Loss of muscle control
  • Restlessness
  • Stomach pain
  • Headache

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Abnormal heart rhythm: chest pounding, short of breath, chest pain, feeling faint or lightheaded
  • Neuroleptic malignant syndrome (NMS): fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
  • Serious infection: fever, pale skin, fast heart rate, lightheadedness, feeling unwell
  • Stroke: sudden numbness in your face, arms, or legs (especially on one side of your body), or if you have sudden trouble speaking, seeing, walking, or understanding people

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • High fever, stiff muscles, increased sweating, fast or irregular heartbeat, and confusion, which may be signs of neuroleptic malignant syndrome
  • High prolactin level—unexpected breast tissue growth, discharge from the nipple, change in sex drive or performance, irregular menstrual cycle
  • Infection—fever, chills, cough, or sore throat
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
  • Seizures
  • Trouble passing urine
  • Uncontrolled and repetitive body movements, muscle stiffness or spasms, tremors or shaking, loss of balance or coordination, restlessness, shuffling walk, which may be signs of extrapyramidal symptoms (EPS)

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Haloperidol injection

thumbs-up

Pros

Typically given monthly

Low risk for weight gain, compared to some other antipsychotics

Available as a lower-cost, generic medication

thumbs-down

Cons

Needs to be injected

Higher risk of movement-related side effects compared to atypical antipsychotics

Can't be used in children

pharmacist-tips

Pharmacist tips for Haloperidol injection

pharmacist
  • Haloperidol injection can make you sleepy. Don't drive or do anything requiring concentration until you know how this medication affects you.

    • Avoid drinking alcohol while taking haloperidol injection because it can make you sleepier, drop your blood pressure, and raise your risk of accidental injuries.

      • It might take some time before you find the dose that works best for you. Don't stop taking haloperidol injections without talking to your provider first, even if you don't feel better.

        • There have been reports of people feeling weakness, fever, confusion, and uncontrollable muscle contractions and movements when taking lithium (Lithobid) and haloperidol injection together. Let your provider know if you're taking lithium and if you get any of these side effects while taking both medications.

          faqs

          Frequently asked questions about Haloperidol injection

          How long does it take haloperidol injection to work?
          Because haloperidol injection is slowly released in your body, it can take a few weeks before you notice the benefits of this medication. If you and your provider are considering haloperidol injection as a possible treatment, your provider will probably have you try oral haloperidol tablets first. This is so that you know how haloperidol affects you and whether or not you can tolerate its side effects before you start receiving the longer-acting injection. Once you start receiving haloperidol injection, your provider might have you continue taking haloperidol tablets for a few weeks until the effects of the haloperidol injection kicks in.
          How long does haloperidol injection last?
          Typically, you'll need to receive haloperidol injections monthly in order for the levels of this medication to remain stable in your body.
          Does haloperidol injection make you sleepy?
          The long-acting haloperidol injection (haldoperidol decanoate) is unlikely to cause sleepiness. But people who've received the short-acting haloperidol injection have reported sleepiness and sedation. If you're starting haloperidol injection for the first time, don't drive or doing any activities that require you to be alert until you know how this medication affects you.
          Does haloperidol injection cause weight gain?
          While possible, it's unlikely for you to experience weight gain from haloperidol injection. You're less likely to gain weight from haloperidol injection compared to from some other antipsychotics, such as olanzapine (Zyprexa) or quetiapine (Seroquel). To minimize your risk for weight gain while taking haloperidol injection, make sure to have a healthy diet and regular exercise routine.
          Can I take haloperidol by mouth instead of getting an injection?
          Yes, haloperidol is available as tablets and a solution that you can take by mouth. One difference between haloperidol injection and oral haloperidol is how often you need to take your dose. You'll need to receive a haloperidol injection monthly for it to best control your symptoms. But you need to take the haloperidol tablets or solution every day in order for the medication to work. Speak with your provider about which form of haloperidol is best for you.
          Can I take haloperidol injection if I'm pregnant?
          There isn't enough information available to know if haloperidol injection is safe to take during pregnancy or while breastfeeding. Studies do show that babies born to mothers who received haloperidol in the third trimester of pregnancy can experience withdrawal symptoms, such as agitation, trouble breathing, poor feeding, right after birth. If you're pregnant or thinking of becoming pregnant, talk to your provider to discuss the risks and benefits of taking haloperidol injection.
          Can haloperidol injection be given as an intravenous (IV) injection?
          Haloperidol injection isn't FDA-approved to be given as an IV injection. It's only given as an injection into the muscles. But research shows that healthcare providers sometimes give the fast-acting haloperidol injection through the veins in the hospital setting.
          GoodRxEducationalIcon

          How to save using GoodRx

          Compare Prices
          1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
          Select your free coupon
          2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
          Show coupon to your pharmacist
          3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
          Get free couponLearn more
          warings-icon

          What are the risks and warnings for Haloperidol injection?

          Haloperidol injection can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Higher risk of death in older people with dementia-related psychosis

          • Risk factors: Age 65 and older with dementia and psychosis

            People 65 years and older with dementia sometimes have delusions and hallucinations (believing, seeing, or hearing things that aren't real). This is called dementia-related psychosis. Older people with dementia-related psychosis have a higher risk of death if they take medications like haloperidol injection. Because of this risk, haloperidol injection shouldn't be used in people 65 years and older with dementia-related psychosis. Let your provider know if you or someone you know has dementia before starting haloperidol injection.

            In addition, older patients with dementia-related psychosis treated with some antipsychotics had a higher risk of stroke. Seek medical help immediately if you experience sudden numbness in your face, arms, or legs (especially on one side of your body), or if you have sudden trouble speaking, seeing, walking, or understanding people.

            risk-warning

            Life-threatening abnormal heart rhythm (QT prolongation)

            • Risk factors: Low potassium or magnesium blood levels | Older age | Using other medications that cause QT prolongation | Born with QT prolongation | Hypothyroidism (low thyroid hormone) | History of heart problems or abnormal heart rhythms (arrhythmias) | Slow heart rate

              Although rare, haloperidol injection can affect your heart rhythm by prolonging the time period from when the heart pumps and then relaxes. This is known as QT prolongation and it can be life-threatening. Your risk for QT prolongation is higher if you have any of the risk factors listed above. Depending on your risks for QT prolongation, your provider might check your heart rhythm from time to time with an electrocardiogram (EKG). Make sure to tell your provider about all the medications you're taking and don't start any new medications while taking haloperidol injection without talking to your provider or pharmacist first. People who were born with QT prolongation or have a history of arrhythmias should avoid taking haloperidol injection. If you feel your chest pounding, have trouble breathing, chest pain, or feel lightheaded while taking haloperidol injection, call 911 right away.

              risk-warning

              Difficulty controlling body movements

              • Risk factors: Taking other antipsychotic medications | Older age | Female sex | High dose | Taking haloperidol injection for a long period of time | Parkinson's disease | Lewy body dementia

                Antipsychotic medications like haloperidol injection can cause uncontrolled body movements, such as eye-twitching or lip-smacking. Your risk of this happening is more likely the longer you take medications like haloperidol injection and if you're taking a higher dose. If you have Parkinson's disease or certain types of dementia, your risk is higher and you shouldn't take haloperidol injection. These movement problems can become permanent. If you experience any uncontrolled movements and aren't able to stop them, talk to your provider right away.

                risk-warning

                Neuroleptic malignant syndrome (NMS)

                • Risk factors: Taking antipsychotic medications

                  Taking antipsychotic medications like haloperidol injection can cause a rare, but life-threatening condition called neuroleptic malignant syndrome (NMS). Symptoms include fever, sweating, stiff muscles, confusion, not aware of your surroundings, and fast or irregular heartbeat. If you experience any of these symptoms while taking haloperidol injection, seek medication attention as soon as possible. Your provider will likely have you stop taking haloperidol injection and switch you to something else.

                  risk-warning

                  Higher risk of falls

                  • Risk factors: Low blood pressure | Taking medications that lower blood pressure | History of medical conditions that can lower blood pressure

                    Haloperidol injection can make you tired, lower your blood pressure, or cause you to lose your balance, which can lead to falls and injuries. When standing from a sitting or lying position, make sure to get up slowly and hold onto something. If you have concerns, speak to your provider.

                    risk-warning

                    Pneumonia

                    • Risk factors: Older age | Breathing problems | Smoker

                      Some cases of bronchopneumonia, a type of infection in your lungs where your lungs get inflamed, have been reported after using antipsychotics like haloperidol injection. Your risk is higher if you're older in age, smoke, or have breathing problems. Seek medical attention immediately if you experience a fever, cough, or trouble breathing.

                      risk-warning

                      Low white blood cell counts

                      • Risk factors: History of low blood cell counts

                        Though not common, haloperidol injection can lower your white blood cell counts, especially if they've been low previously from other conditions. This can raise your risk of serious infection. You'll need to get blood tests done regularly during the first few months of taking haloperidol injection so your provider can make sure your blood cell counts are in the normal range. If your blood counts drop too low, you'll likely need to stop taking haloperidol injections. If you develop any signs of infection, such as fever, tiredness, chills, cough, or trouble breathing, and they don't go away, contact your provider right away.

                        risk-warning

                        Harm to unborn babies

                        Haloperidol injection should only be used in pregnancy if the benefits outweigh the potential risks to your unborn baby. Newborn babies exposed to haloperidol during the third trimester of pregnancy are at a higher risk for side effects and withdrawal symptoms following delivery. Let your healthcare provider know if you're pregnant or plan to become pregnant while taking haloperidol injection.

                        dosage

                        Haloperidol injection dosage forms

                        The average cost for 1 vial of 1ml of 100mg/ml of Haloperidol injection is $19.15 with a free GoodRx coupon. This is 68.61% off the average retail price of $61.01.
                        ampule
                        Ampule
                        DosageQuantityPrice as low asPrice per unit
                        1ml of 50mg/ml1 ampule$13.96$13.96
                        1ml of 100mg/ml1 ampule$17.66$17.66
                        vial
                        Vial
                        DosageQuantityPrice as low asPrice per unit
                        1ml of 50mg/ml1 vial$13.96$13.96
                        5ml of 50mg/ml1 vial$35.40$35.40
                        1ml of 100mg/ml1 vial$19.15$19.15
                        5ml of 100mg/ml1 vial$55.80$55.80

                        Typical dosing for Haloperidol injection

                        • Your provider will determine your dose of haloperidol injection based on different factors, such as what dose of oral haloperidol you've been taking, your age, and your symptoms. This medication is injected into the muscle and typically given once a month by a healthcare provider in a clinic setting.

                        Haloperidol is also available as a quick-acting injection to treat agitation from schizophrenia that's given into the muscles by a healthcare provider in a hospital setting.

                        More on Haloperidol injection dosage forms

                        interactions

                        Interactions between Haloperidol injection and other drugs

                        Haloperidol injection may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Haloperidol injection. Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        contraindications-icon

                        Haloperidol injection contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Haloperidol injection will not be safe for you to take.
                        alternatives

                        What are alternatives to Haloperidol injection?

                        There are a number of medications that your doctor can prescribe in place of Haloperidol injection. Compare a few possible alternatives below.
                        Haloperidol injection
                        Used for:
                        • Schizophrenia

                        $13.96 Lowest GoodRx priceView Prices
                        Used for:
                        • Psychotic disorders

                        $23.09 Lowest GoodRx priceView Prices
                        Used for:
                        $8.98 Lowest GoodRx priceView Prices

                        Get savings updates for Haloperidol injection

                        Receive price alerts, news, and other messages from GoodRx about Haloperidol injection and other healthcare topics and relevant savings offers.

                        By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                        References

                        Best studies we found

                        Beach, S. R., et al. (2020). Intravenous haloperidol: A systematic review of side effects and recommendations for clinical use. General Hospital Psychiatry.

                        Dayabandara, M., et al. (2017). Antipsychotic-associated weight gain: Management strategies and impact on treatment adherence. Neuropsychiatric Disease and Treatment.

                        Dzahini, O., et al. (2018). Antipsychotic drug use and pneumonia: Systematic review and meta-analysis. Journal of Psychopharmacology.

                        View All References (6)

                        Farzam, K., et al. (2023). QT prolonging drugs. StatPearls.

                        Gland Pharma Limited. (2022). Haloperidol injection [package insert]. DailyMed.

                        Janssen Pharmaceuticals, Inc. (2023). Haldol decanoate- haloperidol decanoate injection [package insert]. DailyMed.

                        National Institute on Aging. (2021). What is Lewy body dementia? Causes, symptoms, and treatments.

                        Rahman, S., et al. (2023). Haloperidol. StatPearls.

                        Riboldi, I., et al. (2022). Practical guidance for the use of long-acting injectable antipsychotics in the treatment of schizophrenia. Psychology Research and Behavior Management.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                        Was this page helpful?

                        Browse medications

                        View All

                        Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.