Key takeaways
Haldol (haloperidol) and Aristada (aripiprazole lauroxil) are both injectable medications used to treat schizophrenia, but they have some key differences. Haldol is a typical antipsychotic that works by blocking dopamine, while Aristada is an atypical antipsychotic that balances both dopamine and serotonin. Haldol is usually given monthly, but it can also be administered as a short-acting injection in hospital settings for agitation. Aristada, on the other hand, can be given every 1 to 2 months, isn't short-acting, and requires you to tolerate Abilify (aripiprazole) tablets first. Haldol has a higher risk of movement-related side effects, such as rigid muscles and tremors, whereas Aristada can cause high blood sugar and weight gain. Additionally, Haldol is available as a lower-cost generic, while Aristada is only available as a brand medication and can be more expensive. Both medications should not be used in older adults with dementia-related psychosis due to a higher risk of death.
