Key takeaways
Loxapine (generic, formerly sold as Loxitane) and quetiapine (Seroquel) are both antipsychotic medications, but they belong to different classes. Loxapine is a first-generation (typical) antipsychotic, while quetiapine is an atypical antipsychotic. Loxapine is primarily used to treat schizophrenia and is known for causing more movement-related side effects, such as shakiness and stiffness. Quetiapine, on the other hand, is used to treat schizophrenia, bipolar disorder, and as an add-on for depression in its extended-release form. Quetiapine is less likely to cause movement problems but can lead to weight gain, high blood sugar, and high cholesterol. Both medications are available in generic forms and are taken orally. Loxapine is typically taken once or twice daily, while quetiapine's dosing can vary from twice to three times daily for immediate-release forms and once daily for extended-release forms. Both medications have serious side effects, including the risk of neuroleptic malignant syndrome and low white blood cell counts, but quetiapine also carries a risk of suicidal thoughts, especially in younger individuals.
