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Compare Loxapine vs. Thiothixene

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Loxapine (generic name: loxapine) and Thiothixene (generic name: thiothixene) are both first-generation antipsychotics used to treat schizophrenia, but they have some differences. Loxapine is typically taken once or twice daily, while Thiothixene is usually taken multiple times a day. Loxapine can cause more movement-related side effects compared to atypical antipsychotics, and it can also cause drowsiness, dizziness, and a drop in blood pressure. Thiothixene, on the other hand, is more likely to cause uncontrolled muscle movements but is less likely to cause anticholinergic side effects like dry mouth and constipation. Both medications can cause serious side effects like neuroleptic malignant syndrome and low white blood cell counts. Loxapine is available as a generic capsule, while Thiothixene is available as a generic and in various strengths. Neither medication should be used in older adults with dementia-related psychosis due to an increased risk of death.

  • Loxapine
    Thiothixene
  • Loxapine
    Thiothixene

  • Summary of Loxapine vs. Thiothixene

    Summary for First-generation (typical) antipsychotic
    Prescription only

    Loxapine is a typical antipsychotic used to treat schizophrenia. Loxapine is taken by mouth, typically once or twice daily. It can cause more movement-related side effects compared with atypical antipsychotics, such as aripiprazole (Abilify). It used to be sold under the brand name Loxitane, which is no longer available. Oral loxapine is now only available as generic capsules.

    Summary for First-generation (typical) antipsychotic
    Prescription only

    Thiothixene is used to treat schizophrenia in people ages 12 years and older. It belongs to a drug class known as typical antipsychotics. This medication comes as a oral capsule and it's typically taken 2-3 times a day. Some of the more common side effects of this medication include drowsiness, restlessness, and uncontrolled body movement. Thiothixene is only available as a generic medication. Brand name Navane has been discontinued.

  • Indications of Loxapine vs. Thiothixene

    Indications for
    •Schizophrenia
    Indications for
    •Schizophrenia in people ages 12 years and older

  • Pros and Cons of Loxapine vs. Thiothixene

    Pros and Const for First-generation (typical) antipsychotic
    Pros
    •A good option if other schizophrenia medications haven't worked or have caused bothersome side effects
    •Dose can be adjusted by your provider based on your response
    •Available as a lower-cost generic medication
    Cons
    •More likely to cause trouble controlling movements compared to other treatment options
    •Can raise your heart rate and lower your blood pressure
    •Risk of developing abnormal muscle movements that might not go away after you stop taking loxapine
    Pros and Const for First-generation (typical) antipsychotic
    Pros
    •Taken by mouth
    •Can be taken by children as young as 12 years old
    •Dose can be adjusted based on your response
    Cons
    •Might need to take up to 3 times a day
    •Can cause low white blood cell counts so might need to have regular blood tests done
    •More likely to cause movement-related problems than atypical antipsychotics

  • Common Side Effects of Loxapine vs. Thiothixene

    Common Side Effects for
    •Drowsiness
    •Extrapyramidal symptoms (movement problems, such as shakiness, stiffness, excess saliva, and loss of facial expression)
    •Restless muscles (akathisia)
    Common Side Effects for
    •Drowsiness
    •Trouble sleeping
    •Restlessness
    •Uncontrollable body movement

  • Warnings of Loxapine vs. Thiothixene

    Common Side Effects for
    •Higher risk of death in older adults
    •Uncontrollable body movements (tardive dyskinesia)
    •Neuroleptic malignant syndrome
    •Falls
    •Low white blood cell count
    •Seizures
    •Vision changes
    •High prolactin levels
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Abnormal and prolonged muscle contractions (dystonia)
    •Neuroleptic malignant syndrome (NMS)
    •Seizures
    •Drowsiness and sleepiness
    •Low white blood cell count
    •Vision changes
    •High prolactin levels

  • Prices with our coupons for Loxapine vs. Thiothixene

    Learn more about Loxapine
    Learn more about Thiothixene

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