Key takeaways
Loxapine (generic name: loxapine) and Thiothixene (generic name: thiothixene) are both first-generation antipsychotics used to treat schizophrenia, but they have some differences. Loxapine is typically taken once or twice daily, while Thiothixene is usually taken multiple times a day. Loxapine can cause more movement-related side effects compared to atypical antipsychotics, and it can also cause drowsiness, dizziness, and a drop in blood pressure. Thiothixene, on the other hand, is more likely to cause uncontrolled muscle movements but is less likely to cause anticholinergic side effects like dry mouth and constipation. Both medications can cause serious side effects like neuroleptic malignant syndrome and low white blood cell counts. Loxapine is available as a generic capsule, while Thiothixene is available as a generic and in various strengths. Neither medication should be used in older adults with dementia-related psychosis due to an increased risk of death.
