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Compare Seroquel vs. Aristada

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Quetiapine (Seroquel) and Aristada (aripiprazole lauroxil) are both atypical antipsychotics used to treat schizophrenia, but they have some key differences. Quetiapine can also treat bipolar disorder and depression. Quetiapine is available in both immediate-release and extended-release oral tablets, while Aristada is a long-acting injection given by a healthcare professional. Aristada is administered every 1 to 2 months, making it a good option for those who have trouble taking daily medications, while quetiapine needs to be taken 2 to 3 times a day. Both medications can cause high blood sugar and weight gain, but Aristada has fewer side effects overall. Quetiapine is available as a lower-cost generic, but Aristada is only available as a brand medication, which can make it more expensive.

Quetiapine (Seroquel)
Aristada (aripiprazole lauroxil)
Quetiapine (Seroquel)
Aristada (aripiprazole lauroxil)
Summary of Seroquel vs. Aristada
Summary for Atypical antipsychotic
Prescription only
Quetiapine (Seroquel) is an atypical antipsychotic that's used to improve mood, thoughts, and behaviors for people with schizophrenia and bipolar disorder. The extended-release form of quetiapine (Seroquel) can also be used to treat depression when combined with another antidepressant. While quetiapine (Seroquel) works well, it has many risks and side effects, so it's not the best choice for everyone. Make sure your provider knows about all of your medical conditions and medications you're taking before starting quetiapine (Seroquel) to make sure it's as safe for you as possible.
Summary for Atypical antipsychotic
Prescription only
Aristada (aripiprazole lauroxil) is used to improve mood, thoughts, and behaviors in adults who have schizophrenia. It's a long-acting medication that's injected into your muscle every 1 to 2 months by your healthcare provider. It's only used in people who can tolerate Abilify (aripiprazole) oral tablets.
Indications of Seroquel vs. Aristada
Indications for

•Schizophrenia in adults and children age 13 years and older

•Bipolar disorder in adults and children age 10 years and older

•Add-on to antidepressants for depression (extended-release only)

Indications for

•Schizophrenia
Pros and Cons of Seroquel vs. Aristada
Pros and Const for Atypical antipsychotic
Pros

•Might notice an improvement in your symptoms in as early as a week of starting quetiapine (Seroquel)

•Taken by mouth

•Extended-release quetiapine (Seroquel) can help treat depression (adults only)

•Available as a lower-cost generic

•Available in both short-acting and long-acting forms

Cons

•Can cause weight gain and can raise your blood sugar and blood cholesterol levels

•Must be avoided in older adults who have dementia-related psychosis

•Can raise the risk of suicidal thoughts and behaviors, especially in people who are age 24 or younger

•Need to take immediate-release tablets 2 to 3 times a day

Pros and Const for Atypical antipsychotic
Pros

•Can be given up to once every 2 months

•Good option for people who have a hard time taking medications by mouth

•Has fewer side effects compared to some other antipsychotic medications

•Patient assistance programs are available to help lower the cost

Cons

•Can cause high blood sugar and weight gain

•Must be injected in the muscle at your healthcare provider's office

•Can cause soreness or pain at the injection site

•Not recommended for use during pregnancy or breastfeeding

•Can be expensive because it's only available as a brand medication
Common Side Effects of Seroquel vs. Aristada
Common Side Effects for
Immediate-release tablets

•Headache (21%)

•Agitation (20%)

•Sleepiness (18%)

•Dizziness (11%)

•Dry mouth (9%)

•Constipation (8%)

•Pain (7%)

Extended-release tablets

•Sleepiness (25-52%)

•Dry mouth (12-37%)

•Dizziness (10-13%)

•Constipation (6-10%)

•Difficulty controlling muscle movements (7-8%)

•Weight gain (7%)

Common Side Effects for

•Restlessness (11%)

•Unusual and uncontrollable muscle movements or muscle spasms (5-7%)
Warnings of Seroquel vs. Aristada
Common Side Effects for

•Higher risk of death in older people with dementia-related psychosis

•Worsening depression, suicidal thoughts and behavior

•Neuroleptic malignant syndrome

•Weight gain and high levels of blood sugar and cholesterol

•Difficulty controlling body movements

•Changes in blood pressure and higher risk of falls

•Risk of infection (from low white blood cell count)

•Life-threatening abnormal heart rhythm (QT prolongation)

•Seizures

•Hypothyroidism (low thyroid hormone)

•High prolactin levels

•Difficulty concentrating and extreme sleepiness

Common Side Effects for

•Higher risk of death in older adults with dementia-related psychosis

•Neuroleptic malignant syndrome (NMS)

•Difficulty controlling muscle movements (tardive dyskinesia)

•High blood sugar, high cholesterol, and weight gain

•Impulsive behavior

•Higher risk of falls

•Higher risk of infections

•Seizures
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Compare Seroquel vs. Aristada

Key takeaways

Summary of Seroquel vs. Aristada

Indications of Seroquel vs. Aristada

Pros and Cons of Seroquel vs. Aristada

Common Side Effects of Seroquel vs. Aristada

Warnings of Seroquel vs. Aristada

Prices with our coupons for Seroquel vs. Aristada

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