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Compare Thiothixene vs. Seroquel

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Thiothixene (Navane) and quetiapine (Seroquel and Seroquel XR) are both used to treat schizophrenia, but they belong to different classes of antipsychotics. Thiothixene is a first-generation (typical) antipsychotic, while quetiapine is a second-generation (atypical) antipsychotic. Thiothixene works by lowering dopamine levels in the brain, which can help with symptoms like hallucinations and delusions. However, it can cause more uncontrolled muscle movements compared to quetiapine. On the other hand, quetiapine affects both dopamine and serotonin levels and is also used to treat bipolar disorder and as an add-on for depression. Quetiapine is more likely to cause weight gain and raise blood sugar and cholesterol levels. Both medications are available in generic forms, but quetiapine offers both immediate-release and extended-release options, which can be more convenient.

Thiothixene
Quetiapine (Seroquel)
Thiothixene
Quetiapine (Seroquel)
Summary of Thiothixene vs. Seroquel
Summary for First-generation (typical) antipsychotic
Prescription only
Thiothixene is used to treat schizophrenia in people ages 12 years and older. It belongs to a drug class known as typical antipsychotics. This medication comes as a oral capsule and it's typically taken 2-3 times a day. Some of the more common side effects of this medication include drowsiness, restlessness, and uncontrolled body movement. Thiothixene is only available as a generic medication. Brand name Navane has been discontinued.
Summary for Atypical antipsychotic
Prescription only
Quetiapine (Seroquel) is an atypical antipsychotic that's used to improve mood, thoughts, and behaviors for people with schizophrenia and bipolar disorder. The extended-release form of quetiapine (Seroquel) can also be used to treat depression when combined with another antidepressant. While quetiapine (Seroquel) works well, it has many risks and side effects, so it's not the best choice for everyone. Make sure your provider knows about all of your medical conditions and medications you're taking before starting quetiapine (Seroquel) to make sure it's as safe for you as possible.
Indications of Thiothixene vs. Seroquel
Indications for

•Schizophrenia in people ages 12 years and older

Indications for

•Schizophrenia in adults and children age 13 years and older

•Bipolar disorder in adults and children age 10 years and older

•Add-on to antidepressants for depression (extended-release only)
Pros and Cons of Thiothixene vs. Seroquel
Pros and Const for First-generation (typical) antipsychotic
Pros

•Taken by mouth

•Can be taken by children as young as 12 years old

•Dose can be adjusted based on your response

Cons

•Might need to take up to 3 times a day

•Can cause low white blood cell counts so might need to have regular blood tests done

•More likely to cause movement-related problems than atypical antipsychotics

Pros and Const for Atypical antipsychotic
Pros

•Might notice an improvement in your symptoms in as early as a week of starting quetiapine (Seroquel)

•Taken by mouth

•Extended-release quetiapine (Seroquel) can help treat depression (adults only)

•Available as a lower-cost generic

•Available in both short-acting and long-acting forms

Cons

•Can cause weight gain and can raise your blood sugar and blood cholesterol levels

•Must be avoided in older adults who have dementia-related psychosis

•Can raise the risk of suicidal thoughts and behaviors, especially in people who are age 24 or younger

•Need to take immediate-release tablets 2 to 3 times a day
Common Side Effects of Thiothixene vs. Seroquel
Common Side Effects for

•Drowsiness

•Trouble sleeping

•Restlessness

•Uncontrollable body movement

Common Side Effects for
Immediate-release tablets

•Headache (21%)

•Agitation (20%)

•Sleepiness (18%)

•Dizziness (11%)

•Dry mouth (9%)

•Constipation (8%)

•Pain (7%)

Extended-release tablets

•Sleepiness (25-52%)

•Dry mouth (12-37%)

•Dizziness (10-13%)

•Constipation (6-10%)

•Difficulty controlling muscle movements (7-8%)

•Weight gain (7%)
Warnings of Thiothixene vs. Seroquel
Common Side Effects for

•Higher risk of death in older adults with dementia-related psychosis

•Difficulty controlling muscle movements (tardive dyskinesia)

•Abnormal and prolonged muscle contractions (dystonia)

•Neuroleptic malignant syndrome (NMS)

•Seizures

•Drowsiness and sleepiness

•Low white blood cell count

•Vision changes

•High prolactin levels

Common Side Effects for

•Higher risk of death in older people with dementia-related psychosis

•Worsening depression, suicidal thoughts and behavior

•Neuroleptic malignant syndrome

•Weight gain and high levels of blood sugar and cholesterol

•Difficulty controlling body movements

•Changes in blood pressure and higher risk of falls

•Risk of infection (from low white blood cell count)

•Life-threatening abnormal heart rhythm (QT prolongation)

•Seizures

•Hypothyroidism (low thyroid hormone)

•High prolactin levels

•Difficulty concentrating and extreme sleepiness
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Compare Thiothixene vs. Seroquel

Key takeaways

Summary of Thiothixene vs. Seroquel

Indications of Thiothixene vs. Seroquel

Pros and Cons of Thiothixene vs. Seroquel

Common Side Effects of Thiothixene vs. Seroquel

Warnings of Thiothixene vs. Seroquel

Prices with our coupons for Thiothixene vs. Seroquel

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