Key takeaways
Thiothixene (Navane) and ziprasidone (Geodon) are both used to treat schizophrenia, but they belong to different classes of antipsychotics. Thiothixene is a first-generation (typical) antipsychotic, while ziprasidone is a second-generation (atypical) antipsychotic. Thiothixene is only available in an oral form and is known to cause more uncontrolled muscle movements compared to other antipsychotics. On the other hand, ziprasidone can be taken orally or as an injection and is also used to treat bipolar I disorder. Ziprasidone is less likely to cause weight gain but must be taken with food to ensure proper absorption. Both medications can cause sleepiness and have serious side effects, such as neuroleptic malignant syndrome and tardive dyskinesia, but ziprasidone also carries a risk of heart rhythm problems. Both medications are available in a generic form, for more cost-effective options.
