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Compare Thiothixene vs. Geodon

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Thiothixene (Navane) and ziprasidone (Geodon) are both used to treat schizophrenia, but they belong to different classes of antipsychotics. Thiothixene is a first-generation (typical) antipsychotic, while ziprasidone is a second-generation (atypical) antipsychotic. Thiothixene is only available in an oral form and is known to cause more uncontrolled muscle movements compared to other antipsychotics. On the other hand, ziprasidone can be taken orally or as an injection and is also used to treat bipolar I disorder. Ziprasidone is less likely to cause weight gain but must be taken with food to ensure proper absorption. Both medications can cause sleepiness and have serious side effects, such as neuroleptic malignant syndrome and tardive dyskinesia, but ziprasidone also carries a risk of heart rhythm problems. Both medications are available in a generic form, for more cost-effective options.

  • Thiothixene
    Ziprasidone (Geodon)
  • Thiothixene
    Ziprasidone (Geodon)

  • Summary of Thiothixene vs. Geodon

    Summary for First-generation (typical) antipsychotic
    Prescription only

    Thiothixene is used to treat schizophrenia in people ages 12 years and older. It belongs to a drug class known as typical antipsychotics. This medication comes as a oral capsule and it's typically taken 2-3 times a day. Some of the more common side effects of this medication include drowsiness, restlessness, and uncontrolled body movement. Thiothixene is only available as a generic medication. Brand name Navane has been discontinued.

    Summary for Atypical antipsychotic
    Prescription only

    Ziprasidone (Geodon) is an atypical antipsychotic medication used to treat bipolar I disorder and schizophrenia in adults. It works by balancing the levels of certain chemicals in the brain, like dopamine and serotonin. Ziprasidone (Geodon) is taken by mouth, typically twice daily. It's also available as an injection that's given into the muscles by a healthcare provider to treat agitation in schizophrenia. Some common side effects of ziprasidone (Geodon) include uncontrolled body movements, sleepiness, and nausea.

  • Indications of Thiothixene vs. Geodon

    Indications for
    •Schizophrenia in people ages 12 years and older
    Indications for
    •Bipolar I disorder
    •Schizophrenia

  • Pros and Cons of Thiothixene vs. Geodon

    Pros and Const for First-generation (typical) antipsychotic
    Pros
    •Taken by mouth
    •Can be taken by children as young as 12 years old
    •Dose can be adjusted based on your response
    Cons
    •Might need to take up to 3 times a day
    •Can cause low white blood cell counts so might need to have regular blood tests done
    •More likely to cause movement-related problems than atypical antipsychotics
    Pros and Const for Atypical antipsychotic
    Pros
    •Taken by mouth
    •Less likely to weight gain than other similar medications
    •Available as a lower-cost generic medication
    Cons
    •Taken twice daily
    •Might take several weeks before you feel the full benefits of this medication
    •Must be taken with food

  • Common Side Effects of Thiothixene vs. Geodon

    Common Side Effects for
    •Drowsiness
    •Trouble sleeping
    •Restlessness
    •Uncontrollable body movement
    Common Side Effects for
    •Uncontrolled body movements (14%)
    •Sleepiness (14%)
    •Nausea (10%)
    •Constipation (9%)
    •Indigestion (8%)
    •Restlessness (8%)
    •Dizziness (8%)
    •Respiratory tract infection (8%)

    Note: Side effects listed were reported by people who took ziprasidone for schizophrenia in a clinical study

  • Warnings of Thiothixene vs. Geodon

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Abnormal and prolonged muscle contractions (dystonia)
    •Neuroleptic malignant syndrome (NMS)
    •Seizures
    •Drowsiness and sleepiness
    •Low white blood cell count
    •Vision changes
    •High prolactin levels
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Risk of suicidal thoughts and behavior
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •Neuroleptic malignant syndrome
    •Difficulty concentrating and extreme sleepiness
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Seizures
    •Serious skin reaction
    •Prolonged and painful erection
    •High prolactin levels
    •Heart rhythm problems

  • Prices with our coupons for Thiothixene vs. Geodon

    Learn more about Thiothixene
    Learn more about Ziprasidone

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