Key takeaways
Perphenazine and aripiprazole (Abilify) are both antipsychotic medications, but they belong to different classes and have distinct uses and side effects. Perphenazine is a first-generation (typical) antipsychotic used to treat schizophrenia and severe nausea and vomiting, while aripiprazole is an atypical antipsychotic used for a broader range of conditions, including schizophrenia, bipolar I disorder, and Tourette syndrome. Perphenazine is available in tablet form taken multiple times a day and can cause drowsiness, dizziness, and significant side effects like movement disorders. In contrast, aripiprazole is typically taken once a day and is available in various forms, including a liquid and dissolvable tablets, making it easier for those who have trouble swallowing pills. Both medications are available as low-cost generics. Aripiprazole is less likely to cause weight gain compared to other antipsychotics, but it can still lead to movement problems and has a risk of increasing blood sugar and cholesterol levels. Both medications carry a higher risk of death in older adults with dementia-related psychosis and can cause neuroleptic malignant syndrome, a life-threatening condition.
