Key takeaways
Haloperidol (Haldol) and fluphenazine (Prolixin) are both typical antipsychotics used to treat psychosis, but they have some differences. Haloperidol is mainly used for schizophrenia and is available as oral forms, as well as a long-acting injection given monthly or a short-acting injection for acute agitation. Fluphenazine treats various psychotic disorders and comes in both short-acting forms (tablets, liquid, injection) taken multiple times a day and a long-acting injection given every 4 to 6 weeks. Both medications may cause weight gain and movement-related side effects. Both medications can cause serious side effects like neuroleptic malignant syndrome and are not recommended for older adults with dementia-related psychosis. Fluphenazine can also raise prolactin levels, leading to additional side effects like milky nipple discharge and menstrual issues. Both medications are available as lower-cost generics.
