
chlorpromazine
Chlorpromazine is an antipsychotic medication used to treat many conditions that affect the brain and nervous system, including schizophrenia, bipolar disorder, and ongoing hiccups. It works by blocking certain chemicals in the body, like histamine and dopamine. Your dose depends on why you’re taking it and how severe your symptoms are, but it’s usually taken three or four times a day. Common side effects include drowsiness and movement problems.
What is Chlorpromazine?
What is Chlorpromazine used for?
- Management of psychotic conditions
- Schizophrenia
- Nausea and vomiting
- Restlessness and anxiety before surgery
- Acute intermittent porphyria
- Tetanus
- Manic episodes of bipolar disorder
- Hiccups that won't go away
- Severe behavioral problems in children (ages 1 to 12) with extreme aggression or explosive behavior
- Short-term treatment for children with hyperactivity, focus problems, or mood swings
How Chlorpromazine works
Chlorpromazine is a typical (first-generation) antipsychotic. It works mainly by blocking dopamine in your brain, which helps control your thoughts, mood, and behavior. When dopamine levels are more balanced, symptoms like hallucinations, confusion, and agitation can improve.
chlorpromazine also blocks other chemicals, such as histamine. This can help you feel calmer and can reduce nausea and vomiting.
Drug facts
| Common Brands | Thorazine |
|---|---|
| Drug Class | Typical antipsychotic |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
Side effects of Chlorpromazine
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Drowsiness
- Dry mouth
- Blurred vision
- Constipation
- Urination problems
Less Common Side Effects
- Skin and eye color changes
- Weight gain
- Swelling
- Increased appetite
- Rash
- Sexual problems
Chlorpromazine serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Uncontrolled movement problems: muscle spasms, difficulty swallowing, trouble breathing, tremors, drooling, shuffling walk, sticking out your tongue, puffing your cheeks, puckering your mouth, making repeated chewing movements
- Neuroleptic malignant syndrome: very high fever, stiff muscles, confusion, fast heartbeat, sweating
- Seizures: sudden jerking or shaking, loss of consciousness, confusion, trouble speaking
- Severe skin reaction: rash, blisters, peeling skin
The following Chlorpromazine side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Phenothiazines can sometimes cause serious unwanted effects. Tardive dyskinesia or tardive dystonia (muscle movement disorders) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia or tardive dystonia include worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, body, arms, or legs. Another possible serious unwanted effect is the neuroleptic malignant syndrome (NMS). Signs and symptoms of NMS include severe muscle stiffness, fever, fast heartbeat, difficult breathing, increased sweating, and loss of bladder control. You and your doctor should discuss the good this medicine will do as well as the risks of taking it.
Stop taking this medicine and get emergency help immediately if any of the following effects occur:
Rare
Symptoms of neuroleptic malignant syndrome
Confusion (severe) or coma
difficult or fast breathing
fast heartbeat
high or low (irregular) blood pressure
increased sweating
loss of bladder control
muscle stiffness (severe)
trembling or shaking
trouble in speaking or swallowing
Check with your doctor immediately if any of the following side effects occur:
More common
Inability to move eyes
increased blinking or spasms of eyelid
lip smacking or puckering
muscle spasms of face, neck, body, arms, or legs causing unusual postures or unusual expressions on face
puffing of cheeks
rapid or worm-like movements of tongue
sticking out of tongue
tic-like or twitching movements
trouble in breathing, speaking, or swallowing
uncontrolled chewing movements
uncontrolled movements of arms or legs
uncontrolled twisting movements of neck, trunk, arms, or leg
Rare
Irregular or slow heart rate
recurrent fainting
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Blurred vision, change in color vision, or difficulty in seeing at night
fainting
loss of balance control
mask-like face
restlessness or need to keep moving
shuffling walk
stiffness of arms or legs
trembling and shaking of hands and fingers
Less common
Difficulty in urinating
skin rash
sunburn (severe)
Rare
Abdominal or stomach pains
aching muscles and joints
agitation, bizarre dreams, excitement, or trouble in sleeping
bleeding or bruising (unusual
clumsiness
confusion (mild)
constipation (severe)
convulsions (seizures)
dark urine
fever and chills
headaches
hot, dry skin or lack of sweating
itchy skin (severe)
muscle weakness
pain in joints
prolonged, painful, inappropriate erection of the penis
redness of hands
shivering
skin discoloration (tan or blue-gray)
sore throat and fever
sores in mouth
unusual bleeding or bruising
unusual tiredness or weakness
yellow eyes or skin
Phenothiazines may cause your urine to be dark. In most cases, this is not a sign of a serious problem. However, if your urine does become dark, discuss it with your doctor.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Changes in menstrual period
decreased sexual ability
increased sensitivity of eyes to light
rough or “fuzzy” tongue
secretion of milk (unusual)
swelling or pain in breasts
watering of mouth
weight gain (unusual)
After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this time, check with your doctor if you notice dizziness, nausea and vomiting, stomach pain, trembling of the fingers and hands, or any of the following signs of tardive dyskinesia or tardive dystonia:
Inability to move eyes
lip smacking or puckering
muscle spasms of face, neck, body, arms, or legs, causing unusual body positions or unusual expressions on face
puffing of cheeks
rapid or worm-like movements of tongue
sticking out of tongue
tic-like or twitching movements
trouble in breathing, speaking, or swallowing
uncontrolled chewing movements
uncontrolled twisting or other movements of neck, trunk, arms, or legs
Although not all of the side effects listed above have been reported for all of the phenothiazines, they have been reported for at least one of them. However, since all of the phenothiazines are very similar, any of the above side effects may occur with any of these medicines.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Chlorpromazine
Pros
- Approved to treat several conditions
- Starts working quickly
- Available as a tablet, liquid, and injection
- Dose can be easily adjusted based on your symptoms
Cons
- Needs to be taken multiple times a day
- Commonly causes drowsiness
- Risk of uncontrolled muscle movements
- Not recommended for use in pregnancy
Pharmacist tips for Chlorpromazine
- Take chlorpromazine exactly as your prescriber tells you. Your dose might change over time as your prescriber finds the right dose for you
- Drowsiness is a common side effect of chlorpromazine, especially during the first two weeks. After that, it typically goes away on its own. Be careful with activities that require focus, like driving or using machines.
- Chlorpromazine can cause a drop in blood pressure if you stand up or sit up too quickly. Stand up slowly when getting up from sitting or lying down while taking this medication.
- Avoid drinking alcohol while taking chlorpromazine. Alcohol can make side effects like drowsiness and low blood pressure worse.
- Chlorpromazine can cause serious movement problems if used for a long time. See your prescriber regularly so they can check for side effects.
- Tell your care team about all the medications you take. Chlorpromazine can interact with medications like blood thinners and other medications that make you drowsy.
- Chlorpromazine can make your skin more sensitive to the sun. Wear protective clothing or sunscreen when you go outside.
- Don't stop taking chlorpromazine suddenly unless your prescriber tells you to. Stopping too quickly can cause uncomfortable withdrawal symptoms. So your prescriber might want to lower your dose slowly.
- Chlorpromazine might not be safe during pregnancy unless clearly needed. Tell your prescriber if you're pregnant or planning to become pregnant.
- Chlorpromazine can pass into breast milk. Talk to your prescriber about whether you should stop breastfeeding or stop the medication.
Risks and warnings for Chlorpromazine
Chlorpromazine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Higher risk of death in older adults with dementia
Older adults with dementia can sometimes have symptoms like hallucinations (seeing or hearing things that aren’t there) or delusions (strong beliefs that aren’t true). This is called dementia-related psychosis, and it shouldn't be treated with chlorpromazine. This medication can raise the risk of death in people with this condition. Tell your prescriber if you or your loved one has dementia before starting chlorpromazine.
Uncontrolled muscle movements
- Risk factors: Older adults, especially women | Taking chlorpromazine for a long time | Taking high doses
Antipsychotic medications like chlorpromazine can cause a movement condition called tardive dyskinesia) (TD). TD causes movements you can’t control. These often affect the face, such as frequent blinking, lip smacking, or sticking out your tongue. It happens more often to older adults, especially older women, but can happen to anyone. Let your care team know if this starts to happen to you or a loved one if you're a caregiver. Sometimes TD gets better if chlorpromazine is stopped or the dose is lowered.
Neuroleptic malignant syndrome
Chlorpromazine can cause a rare but life-threatening condition called neuroleptic malignant syndrome (NMS). Symptoms include a very high fever, fast heartbeat, stiff muscles, and confusion. Get medical attention right away if you have any of these symptoms. Your prescriber will likely stop this medication and choose a different one that is safer for you.
Changes in blood cell counts
- Risk factors: History of low white blood cell counts
Chlorpromazine can lower your white blood cell count, which helps your body fight infections. If you get a fever or notice that you are getting sick more often than usual, tell your prescriber right away. They might decide to stop this medication.
High prolactin levels
Chlorpromazine can raise the level of a hormone called prolactin in your blood. High prolactin levels can cause milky discharge from the nipples, breast enlargement, sexual problems, missed or irregular periods, and weak bones. Your prescriber might order blood tests to check that your prolactin levels stay in a healthy range.
Falls and fractures
Chlorpromazine can make you feel sleepy, dizzy when you stand up, or unsteady when you move. This can raise your risk of falling and getting hurt, such as breaking a bone. If you have health conditions or take other medications that can make these effects worse, your prescriber might check your risk of falling when you start treatment and regularly if you take this medication long term.
Chlorpromazine dosage
Typical dosage for Chlorpromazine
Chlorpromazine comes as a tablet and oral liquid concentrate. The dose depends on why you’re taking it.
Adults:
- Psychotic conditions (including schizophrenia and bipolar disorder): In general, the typical dose ranges from 10 mg to 50 mg by mouth two to three times a day.
- Nausea and vomiting: The typical dose is 10 mg to 25 mg by mouth every 4 to 6 hours as needed.
- Restlessness and anxiety before surgery: The typical dose is 25 mg to 50 mg by mouth once, 2 to 3 hours before the procedure.
- Hiccups: The typical dose is 25 mg to 50 mg by mouth three or four times a day.
- Acute intermittent porphyria: The typical dose is 25 mg to 50 mg three or four times a day.
Children:
- Severe behavioral problems: Your child's dose will be based on their weight.
Chlorpromazine is also available as an injection given by a healthcare professional.
Interactions between Chlorpromazine and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
- Alfuzosin
- Amiodarone
- Amisulpride
- Amitriptyline
- Anagrelide
- Apomorphine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Artemether
- Asenapine
- Astemizole
- Atazanavir
- Azithromycin
- Bedaquiline
- Bepridil
- Bromopride
- Buprenorphine
- Buserelin
- Calcium Oxybate
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clorgyline
- Clozapine
- Crizotinib
- Cyclobenzaprine
- Dabrafenib
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Deutetrabenazine
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Dronedarone
- Droperidol
- Duloxetine
- Ebastine
- Efavirenz
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Erythromycin
- Escitalopram
- Famotidine
- Felbamate
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluvoxamine
- Formoterol
- Foscarnet
- Fosphenytoin
- Galantamine
- Gatifloxacin
- Gemifloxacin
- Glasdegib
- Gonadorelin
- Goserelin
- Granisetron
- Halofantrine
- Haloperidol
- Histrelin
- Hydroquinidine
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Inotuzumab Ozogamicin
- Iproniazid
- Isocarboxazid
- Itraconazole
- Ivabradine
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lenvatinib
- Leuprolide
- Levofloxacin
- Levomethadyl
- Lofexidine
- Lorcaserin
- Lumefantrine
- Macimorelin
- Magnesium Oxybate
- Mefloquine
- Mesoridazine
- Methadone
- Metoclopramide
- Metronidazole
- Mifepristone
- Mirabegron
- Mirtazapine
- Mizolastine
- Moclobemide
- Moxifloxacin
- Nafarelin
- Nelfinavir
- Nialamide
- Nilotinib
- Norfloxacin
- Octreotide
- Ofloxacin
- Olanzapine
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Paliperidone
- Panobinostat
- Pargyline
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Pentamidine
- Perphenazine
- Phenelzine
- Pimavanserin
- Pimozide
- Pindolol
- Pipamperone
- Piperaquine
- Pitolisant
- Ponesimod
- Posaconazole
- Potassium Oxybate
- Probucol
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Propranolol
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Ribociclib
- Risperidone
- Ritonavir
- Rolapitant
- Saquinavir
- Selegiline
- Selpercatinib
- Sertindole
- Sertraline
- Sevoflurane
- Sodium Oxybate
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- Sulpiride
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telaprevir
- Telavancin
- Telithromycin
- Terfenadine
- Tetrabenazine
- Thioridazine
- Toloxatone
- Tolterodine
- Toremifene
- Tranylcypromine
- Trazodone
- Triclabendazole
- Trimipramine
- Triptorelin
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vilanterol
- Vinflunine
- Voclosporin
- Voriconazole
- Vorinostat
- Ziprasidone
- Zolmitriptan
- Zotepine
- Zuclopenthixol
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abiraterone Acetate
- Acecainide
- Acepromazine
- Alfentanil
- Alfuzosin
- Alprazolam
- Amifampridine
- Amiodarone
- Amisulpride
- Amitriptyline
- Amobarbital
- Amoxapine
- Anagrelide
- Anileridine
- Apomorphine
- Aprindine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Artemether
- Asenapine
- Astemizole
- Azimilide
- Azithromycin
- Baclofen
- Benperidol
- Benzhydrocodone
- Berotralstat
- Bretylium
- Bromazepam
- Bromopride
- Buprenorphine
- Bupropion
- Buserelin
- Buspirone
- Butabarbital
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Carbamazepine
- Carbinoxamine
- Carisoprodol
- Carphenazine
- Ceritinib
- Cetirizine
- Chloral Hydrate
- Chlordiazepoxide
- Chloroquine
- Chlorpromazine
- Chlorzoxazone
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Crizotinib
- Cyclobenzaprine
- Dabrafenib
- Dacomitinib
- Darifenacin
- Darunavir
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Desmopressin
- Deutetrabenazine
- Dexmedetomidine
- Diacetylmorphine
- Diazepam
- Dibenzepin
- Dichloralphenazone
- Difenoxin
- Dihydrocodeine
- Diphenhydramine
- Diphenoxylate
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Doxorubicin
- Doxorubicin Hydrochloride Liposome
- Doxylamine
- Droperidol
- Efavirenz
- Encainide
- Encorafenib
- Enflurane
- Entrectinib
- Epinephrine
- Erythromycin
- Escitalopram
- Esketamine
- Estazolam
- Eszopiclone
- Ethchlorvynol
- Ethopropazine
- Ethylmorphine
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluphenazine
- Flurazepam
- Fluspirilene
- Formoterol
- Foscarnet
- Fospropofol
- Fostemsavir
- Gabapentin
- Gabapentin Enacarbil
- Gatifloxacin
- Gemifloxacin
- Givosiran
- Glasdegib
- Glucagon
- Glycopyrrolate
- Glycopyrronium Tosylate
- Gonadorelin
- Goserelin
- Granisetron
- Halazepam
- Halofantrine
- Haloperidol
- Halothane
- Hexobarbital
- Histrelin
- Hydrocodone
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Inotuzumab Ozogamicin
- Isoflurane
- Isradipine
- Ivabradine
- Ivosidenib
- Ketamine
- Ketazolam
- Ketobemidone
- Ketoconazole
- Lapatinib
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Levocetirizine
- Levofloxacin
- Levomethadyl
- Levorphanol
- Lidoflazine
- Lithium
- Lofexidine
- Lopinavir
- Lorazepam
- Lorcainide
- Loxapine
- Lumefantrine
- Macimorelin
- Magnesium Oxybate
- Meclizine
- Mefloquine
- Melperone
- Meperidine
- Mephobarbital
- Meprobamate
- Meptazinol
- Mesoridazine
- Metaxalone
- Methacholine
- Methadone
- Methdilazine
- Methocarbamol
- Methohexital
- Methotrimeprazine
- Methylene Blue
- Metoclopramide
- Metrizamide
- Metronidazole
- Midazolam
- Mifepristone
- Milnacipran
- Mirtazapine
- Molindone
- Moricizine
- Morphine
- Morphine Sulfate Liposome
- Moxifloxacin
- Nafarelin
- Nalbuphine
- Nicomorphine
- Nilotinib
- Nitrazepam
- Nitrous Oxide
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ondansetron
- Opium
- Opium Alkaloids
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Panobinostat
- Papaveretum
- Paregoric
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Pentamidine
- Pentazocine
- Pentobarbital
- Perampanel
- Perazine
- Periciazine
- Perphenazine
- Phenobarbital
- Pimavanserin
- Pimozide
- Piperacetazine
- Pipotiazine
- Piritramide
- Pitolisant
- Ponesimod
- Porfimer
- Posaconazole
- Potassium Oxybate
- Prazepam
- Pregabalin
- Primidone
- Probucol
- Procainamide
- Procarbazine
- Prochlorperazine
- Promazine
- Promethazine
- Propafenone
- Propofol
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Remifentanil
- Remimazolam
- Remoxipride
- Revefenacin
- Ribociclib
- Risperidone
- Scopolamine
- Secobarbital
- Secretin Human
- Selegiline
- Selpercatinib
- Sematilide
- Sertindole
- Sertraline
- Sevoflurane
- Siponimod
- Sodium Oxybate
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- Spiramycin
- Succinylcholine
- Sufentanil
- Sulfamethoxazole
- Sulpiride
- Sultopride
- Sunitinib
- Tacrolimus
- Tapentadol
- Tedisamil
- Telavancin
- Telithromycin
- Temazepam
- Tetrabenazine
- Thiethylperazine
- Thiopental
- Thiopropazate
- Thioridazine
- Tilidine
- Tiotropium
- Tizanidine
- Tolonium Chloride
- Topiramate
- Toremifene
- Tramadol
- Tranexamic Acid
- Trazodone
- Triazolam
- Triclabendazole
- Trifluoperazine
- Trifluperidol
- Triflupromazine
- Trimeprazine
- Trimethoprim
- Trimipramine
- Triptorelin
- Vandetanib
- Vardenafil
- Vemurafenib
- Vinflunine
- Voclosporin
- Voriconazole
- Zaleplon
- Zolmitriptan
- Zolpidem
- Zopiclone
- Zotepine
- Zuclopenthixol
How much does Chlorpromazine cost?
$17.19
Chlorpromazine contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Chlorpromazine will not be safe for you to take.
- Phenothiazine allergy
- Taking large doses of sedatives or medications that cloud your thinking (e.g., alcohol, barbiturates, opioids)
- Coma
What are alternatives to Chlorpromazine?
News about Chlorpromazine








