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Compare Thiothixene vs. Risperdal

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Thiothixene (Navane) and risperidone (Risperdal) are both used to treat schizophrenia, but they belong to different classes of antipsychotics. Thiothixene is a first-generation (typical) antipsychotic, while risperidone is a second-generation (atypical) antipsychotic. Thiothixene works by lowering dopamine levels in the brain, whereas risperidone balances both dopamine and serotonin levels. Thiothixene is more likely to cause uncontrolled muscle movements, while risperidone has a higher risk of weight gain and changes in blood sugar and cholesterol levels. Risperidone can also be used to treat bipolar disorder and irritability associated with autism, making it more versatile than thiothixene. Both medications are available in generic forms and should not be mixed with alcohol.

  • Thiothixene
    Risperidone (Risperdal)
  • Thiothixene
    Risperidone (Risperdal)

  • Summary of Thiothixene vs. Risperdal

    Summary for First-generation (typical) antipsychotic
    Prescription only

    Thiothixene is used to treat schizophrenia in people ages 12 years and older. It belongs to a drug class known as typical antipsychotics. This medication comes as a oral capsule and it's typically taken 2-3 times a day. Some of the more common side effects of this medication include drowsiness, restlessness, and uncontrolled body movement. Thiothixene is only available as a generic medication. Brand name Navane has been discontinued.

    Summary for Atypical antipsychotic
    Prescription only

    Risperidone (Risperdal) is an atypical antipsychotic that's used to improve mood, thoughts, and behaviors in people with schizophrenia, bipolar disorder, and autism. It's taken by mouth, typically once or twice daily. Common side effects of risperidone (Risperdal) include sleepiness, movement problems, and weight gain. Risperidone (Risperdal) can interact with some medications, such as certain antidepressants or blood pressure medications. Taking these medications together can make certain side effects worse.

  • Indications of Thiothixene vs. Risperdal

    Indications for
    •Schizophrenia in people ages 12 years and older
    Indications for
    •Schizophrenia - people ages 13 years and older
    •Manic or mixed episodes associated with bipolar I disorder - people ages 10 years and older
    •Irritability associated with autism - children ages 5 to 17 years old

  • Pros and Cons of Thiothixene vs. Risperdal

    Pros and Const for First-generation (typical) antipsychotic
    Pros
    •Taken by mouth
    •Can be taken by children as young as 12 years old
    •Dose can be adjusted based on your response
    Cons
    •Might need to take up to 3 times a day
    •Can cause low white blood cell counts so might need to have regular blood tests done
    •More likely to cause movement-related problems than atypical antipsychotics
    Pros and Const for Atypical antipsychotic
    Pros
    •Taken by mouth
    •Available as a pill, dissolving tablet, and liquid
    •Can be used in both adults and children
    •Available as a lower-cost generic
    Cons
    •Higher risk of sexual problems, compared to other atypical antipsychotics
    •Can cause weight gain
    •Can cause changes to sleep or movement problems
    •Shouldn't be mixed with alcohol

  • Common Side Effects of Thiothixene vs. Risperdal

    Common Side Effects for
    •Drowsiness
    •Trouble sleeping
    •Restlessness
    •Uncontrollable body movement
    Common Side Effects for

    Adults:

    •Muscle stiffness, muscle tightening, difficulty with movement (25%)
    •Extreme sleepiness (11%)
    •Restlessness, trouble remaining still (9%)
    •Tremor (6%)
    •Dizziness (6%)
    •Nausea (5%)
    •Repetitive movements, abnormal postures (5%)

    Children:

    •Extreme sleepiness (up to 56%)
    •Dizziness (up to 16%)
    •Nausea or vomiting (up to 16%)
    •Stomach pain (up to 16%)
    •Muscle stiffness, muscle tightening, difficulty with movement (up to 12%)
    •Heartburn (up to 10%)
    •Sore throat (up to 10%)

  • Warnings of Thiothixene vs. Risperdal

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Abnormal and prolonged muscle contractions (dystonia)
    •Neuroleptic malignant syndrome (NMS)
    •Seizures
    •Drowsiness and sleepiness
    •Low white blood cell count
    •Vision changes
    •High prolactin levels
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •High prolactin levels
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Difficulty concentrating and extreme sleepiness
    •Seizures
    •Prolonged and painful erection
    •Caution use in people with phenylketonuria (PKU) - orally disintegrating tablets only

  • Prices with our coupons for Thiothixene vs. Risperdal

    Learn more about Thiothixene
    Learn more about Risperidone

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