Key takeaways
Thiothixene (Navane) and risperidone (Risperdal) are both used to treat schizophrenia, but they belong to different classes of antipsychotics. Thiothixene is a first-generation (typical) antipsychotic, while risperidone is a second-generation (atypical) antipsychotic. Thiothixene works by lowering dopamine levels in the brain, whereas risperidone balances both dopamine and serotonin levels. Thiothixene is more likely to cause uncontrolled muscle movements, while risperidone has a higher risk of weight gain and changes in blood sugar and cholesterol levels. Risperidone can also be used to treat bipolar disorder and irritability associated with autism, making it more versatile than thiothixene. Both medications are available in generic forms and should not be mixed with alcohol.
