Key takeaways
Thiothixene (Navane) and trifluoperazine (Stelazine) are both first-generation antipsychotics used to treat schizophrenia, but they have some key differences. Thiothixene is only approved for schizophrenia, while trifluoperazine can also be used for anxiety. Thiothixene is not commonly used and can cause more uncontrolled muscle movements compared to other antipsychotics. Trifluoperazine is not recommended for long-term use due to the risk of tardive dyskinesia, a condition that causes trouble controlling movements. Thiothixene is available in many different strengths and is less likely to cause dry mouth, constipation, and blurred vision, but it might need to be taken multiple times a day. On the other hand, trifluoperazine is available in four different strengths and is typically taken twice a day. Both medications can cause drowsiness and should not be used in older adults with dementia-related psychosis due to an increased risk of death. Additionally, both can raise prolactin levels, leading to symptoms like milky discharge from the nipples and irregular menstrual periods.
