Key takeaways
Trifluoperazine and olanzapine (Zyprexa) are both antipsychotic medications, but they belong to different classes and have distinct uses and side effects. Trifluoperazine is a first-generation (typical) antipsychotic mainly used to treat schizophrenia and anxiety, while olanzapine is a second-generation (atypical) antipsychotic used for schizophrenia, bipolar disorder, and certain types of depression when combined with fluoxetine (Prozac). Trifluoperazine is typically taken twice daily and is not recommended for long-term use due to the risk of tardive dyskinesia, a condition causing uncontrollable movements. In contrast, olanzapine is usually taken once daily and can be used long-term, but it has a higher risk of causing weight gain, high blood sugar, and high cholesterol. Both medications can cause drowsiness and dizziness, but olanzapine is more likely to affect your sleep and appetite. Additionally, olanzapine is available in both oral and injectable forms, whereas trifluoperazine is only available in oral form.
