Key takeaways
Haloperidol (Haldol) and quetiapine (Seroquel) are both antipsychotic medications, but they belong to different classes and have distinct uses and side effects. Haloperidol is a typical antipsychotic used mainly for treating schizophrenia and is available as an oral tablet, oral liquid, and an injection, either long-acting or short-acting. It works by blocking dopamine activity in the brain, which can lead to movement-related side effects like rigid muscles and tremors. Quetiapine, on the other hand, is an atypical antipsychotic that treats schizophrenia, bipolar disorder, and can be used as an add-on for depression. It is taken orally and works by balancing dopamine and serotonin levels. Quetiapine is more likely to cause weight gain and increase blood sugar and cholesterol levels, while haloperidol has a lower risk of weight gain but a higher risk of movement-related side effects. Both medications should be used cautiously in older adults with dementia-related psychosis due to an increased risk of death.
