Key takeaways
Haloperidol (Haldol) and chlorpromazine (Thorazine) are both typical antipsychotics, but they have some key differences. Haloperidol is primarily used to treat schizophrenia and is available as an oral tablet, oral liquid, and a long-acting monthly injection or a short-acting injection for acute agitation. In contrast, chlorpromazine has a broader range of uses, including treating schizophrenia, nausea, vomiting, pre-surgery anxiety, and severe behavioral issues in children. Chlorpromazine is usually taken orally but can also be given as an injection. Haloperidol is less likely to cause weight gain compared to chlorpromazine, which can lead to weight gain and increased appetite. Both medications can cause movement-related side effects. Additionally, both haloperidol and chlorpromazine can cause drowsiness. Both medications carry a higher risk of death in older adults with dementia-related psychosis and should not be used to treat dementia-related psychosis.
