Key takeaways
Olanzapine (Zyprexa) and Chlorpromazine (Thorazine) are both antipsychotic medications, but they belong to different classes. Olanzapine is an atypical antipsychotic, while Chlorpromazine is a first-generation (typical) antipsychotic. Olanzapine is used to treat schizophrenia, bipolar disorder, and certain types of depression when combined with fluoxetine (Prozac). In contrast, Chlorpromazine has a broader range of uses, including managing psychotic disorders, schizophrenia, severe behavioral issues in children, and even hiccups that won't go away. Olanzapine is typically taken once daily, either orally or as an injection, whereas Chlorpromazine needs to be taken multiple times a day and is also available in injectable forms. Common side effects of Olanzapine include sleepiness, dizziness, and weight gain, while Chlorpromazine can cause drowsiness, uncontrollable muscle movements, and dry mouth. Both medications carry a higher risk of death in older adults with dementia-related psychosis and can cause serious conditions like neuroleptic malignant syndrome. However, Olanzapine is more likely to cause metabolic issues like high blood sugar and cholesterol levels.
