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Compare Zyprexa vs. Reglan

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Olanzapine (Zyprexa) and metoclopramide (Reglan) are both medications that can be used to treat nausea, although this is an off-label use for olanzapine. Olanzapine is an atypical antipsychotic primarily used for schizophrenia and bipolar disorder, while metoclopramide is a dopamine antagonist used for gastroesophageal reflux disease (GERD) and diabetic gastroparesis. Olanzapine is available in oral and injectable forms, whereas metoclopramide is available in various forms, including tablets, liquid, nasal spray, and injection. Olanzapine is typically taken once daily, while metoclopramide is taken multiple times a day, usually before meals and at bedtime. Common side effects of olanzapine include sleepiness and weight gain, while metoclopramide can cause drowsiness and restlessness. Both medications can cause serious side effects like neuroleptic malignant syndrome and difficulty controlling body movements. Both medications are available as a lower-cost generic.

  • Olanzapine (Zyprexa)
    Metoclopramide (Reglan)
  • Olanzapine (Zyprexa)
    Metoclopramide (Reglan)

  • Summary of Zyprexa vs. Reglan

    Summary for Atypical antipsychotic
    Prescription only

    Olanzapine (Zyprexa) is an atypical antipsychotic used treat schizophrenia or bipolar disorder. It can also treat depression, in combination with fluoxetine (Prozac), when other treatments haven't worked well. This medication is thought to work by balancing the levels of certain chemicals in the brain. Olanzapine (Zyprexa) is taken by mouth, typically once daily, by adults and children. Olanzapine (Zyprexa) is also available as an injection that's usually given in a hospital or clinic setting. Some of the more common side effects of olanzapine (Zyprexa) include sleep problems, dizziness, and weight gain.

    Summary for Dopamine antagonist
    Prescription only

    Metoclopramide (Reglan) is FDA-approved to treat gastroesophageal reflux disease (GERD), as well as gastroparesis in people with diabetes. Providers might also prescribe it off-label for morning sickness during pregnancy and nausea and vomiting caused by chemotherapy. But metoclopramide (Reglan) isn’t a first-choice medication for these conditions because it has a black box warning for a serious side effect called tardive dyskinesia. Metoclopramide (Reglan) can interact with some commonly prescribed medications, such as risperidone (Risperdal) and quetiapine (Seroquel).

  • Indications of Zyprexa vs. Reglan

    Indications for
    •Schizophrenia in adults and children age 13 years and older
    •Bipolar I disorder in adults and children age 13 years and older

    When taken with fluoxetine (Prozac):

    •Bipolar depression in adults and children age 10 years and older
    •Depression that hasn't responded well to other treatments
    Indications for
    •Delayed stomach-emptying caused by diabetes (diabetic gastroparesis)
    •Severe acid reflux (gastroesophageal reflux disease or GERD) when other medications haven’t worked

  • Pros and Cons of Zyprexa vs. Reglan

    Pros and Const for Atypical antipsychotic
    Pros
    •Taken by mouth
    •Taken once daily
    •Might notice an improvement in your symptoms in as early as a week of starting olanzapine (Zyprexa)
    •Available as a lower-cost generic
    Cons
    •Can cause anticholinergic side effects, such as constipation and dry mouth
    •Can affect your sleep
    •More likely to cause weight gain, high blood cholesterol, and high blood sugar levels compared to some other atypical antipsychotics
    Pros and Const for Dopamine antagonist
    Pros
    •Available as a lower-cost generic medication
    •Available in many forms including tablet, fast-melting tablet, liquid, nasal spray, and injection
    •Typically starts to work in 30 minutes to 1 hour
    •A possible option during pregnancy
    Cons
    •Shouldn’t be used in children or for more than 12 weeks because of a higher risk of serious side effects
    •Needs to be taken multiple times a day
    •Interacts with a lot of medications such as antipsychotics, antidepressants, and opioids
    •Can't be used if you have Parkinson's disease, seizures, or stomach blockages or bleeds

  • Common Side Effects of Zyprexa vs. Reglan

    Common Side Effects for
    •Sleepiness (29%)
    •Trouble sleeping (12%)
    •Accidental injury (12%)
    •Dizziness (11%)
    •Weakness (10%)
    •Dry mouth (9%)
    •Constipation (9%)
    •Upset stomach (7%)
    •Runny nose (7%)
    Common Side Effects for
    •Restlessness (10%)
    •Drowsiness (10%)
    •Lack of energy (10%)
    •Tiredness (10%)

  • Warnings of Zyprexa vs. Reglan

    Common Side Effects for
    •Higher risk of death in older people with dementia-related psychosis
    •Worsening depression, suicidal thoughts and behavior
    •Severe allergic skin reactions
    •Neuroleptic malignant syndrome
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •Difficulty controlling body movements
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Seizures
    •High prolactin levels
    •Difficulty concentrating and extreme sleepiness
    •Anticholinergic side effects
    Common Side Effects for
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Other conditions with uncontrolled muscle movements (dystonia, Parkinsonian symptoms, and restlessness)
    •Neuroleptic malignant syndrome (NMS)
    •Depression and suicidal thoughts and behavior
    •High blood pressure
    •Swelling in arms, legs, or around the belly
    •High prolactin levels

  • Prices with our coupons for Zyprexa vs. Reglan

    Learn more about Olanzapine
    Learn more about Metoclopramide

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