Key takeaways
Olanzapine (Zyprexa) and aprepitant (Emend) are both prescription medications that can be used to treat anemia, but they have some important differences. Olanzapine is an atypical antipsychotic approved for schizophrenia and bipolar I disorder and in combination with fluoxetine (Prozac) for certain types of depression. It can also be used off-label for nausea from chemotherapy. Aprepitant, on the other hand, is an NK1 receptor antagonist used to prevent nausea and vomiting caused by chemotherapy. While olanzapine is available in oral and injectable forms, aprepitant is available as oral capsules and an oral solution. Olanzapine is typically taken once daily, while aprepitant is taken over three days during chemotherapy cycles. Common olanzapine side effects include sleepiness, dizziness, and weight gain, whereas aprepitant may cause tiredness, diarrhea, and weakness. Olanzapine can interact with caffeine and alcohol, while aprepitant has many drug interactions. Both medications are available as lower-cost generics.
