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Compare Latuda vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Latuda (lurasidone) and Zyprexa (olanzapine) are both atypical antipsychotics used to treat schizophrenia and bipolar disorder, but they have some key differences. Latuda is available only as an oral tablet, while Zyprexa comes in both oral and injectable forms. Latuda is less likely to cause weight gain compared to Zyprexa, which is known for its higher risk of weight gain and related issues like high blood sugar and cholesterol. Latuda is typically taken once daily with food, whereas Zyprexa can be taken with or without food. They are often taken in the evening due to their sleepiness side effects. Latuda is also associated with movement problems, while Zyprexa can cause anticholinergic side effects like dry mouth and constipation. Additionally, Zyprexa can be used in combination with fluoxetine (Prozac) for treatment-resistant depression, a use not indicated for Latuda.

Latuda (lurasidone)
Olanzapine (Zyprexa)
Latuda (lurasidone)
Olanzapine (Zyprexa)
Summary of Latuda vs. Zyprexa
Summary for Atypical antipsychotic
Prescription only
Latuda (lurasidone) is an atypical antipsychotic that's used to treat schizophrenia in adults and children age 13 years and older. It can also be used for treating depression from bipolar disorder in adults and children age 10 years and older. Latuda (lurasidone) is a tablet that's taken by mouth once per day. The most common side effect is sleepiness, and the medication is less likely to cause weight gain compared to other antipsychotics.
Summary for Atypical antipsychotic
Prescription only
Olanzapine (Zyprexa) is an atypical antipsychotic used treat schizophrenia or bipolar disorder. It can also treat depression, in combination with fluoxetine (Prozac), when other treatments haven't worked well. This medication is thought to work by balancing the levels of certain chemicals in the brain. Olanzapine (Zyprexa) is taken by mouth, typically once daily, by adults and children. Olanzapine (Zyprexa) is also available as an injection that's usually given in a hospital or clinic setting. Some of the more common side effects of olanzapine (Zyprexa) include sleep problems, dizziness, and weight gain.
Indications of Latuda vs. Zyprexa
Indications for

•Schizophrenia in people age 13 years and older

•Depression from bipolar disorder in people age 10 years and older

•Add-on therapy to lithium (Lithobid) or divalproex (Depakote) for depression from bipolar disorder in adults

Indications for

•Schizophrenia in adults and children age 13 years and older

•Bipolar I disorder in adults and children age 13 years and older

When taken with fluoxetine (Prozac):

•Bipolar depression in adults and children age 10 years and older

•Depression that hasn't responded well to other treatments
Pros and Cons of Latuda vs. Zyprexa
Pros and Const for Atypical antipsychotic
Pros

•Works well for depression from bipolar disorder and schizophrenia

•Only need to take it once a day

•Can use in adults and children

•Less likely to affect your weight than other antipsychotics

Cons

•Can take several weeks before you feel the full effects

•Can make you feel sleepy

•Can cause movement problems

•Only available as a tablet

Pros and Const for Atypical antipsychotic
Pros

•Taken by mouth

•Taken once daily

•Might notice an improvement in your symptoms in as early as a week of starting olanzapine (Zyprexa)

•Available as a lower-cost generic

Cons

•Can cause anticholinergic side effects, such as constipation and dry mouth

•Can affect your sleep

•More likely to cause weight gain, high blood cholesterol, and high blood sugar levels compared to some other atypical antipsychotics
Common Side Effects of Latuda vs. Zyprexa
Common Side Effects for

•Sleepiness

•Nausea

•Difficulty moving or slow movements

•Can't stay still

Common Side Effects for

•Sleepiness (29%)

•Trouble sleeping (12%)

•Accidental injury (12%)

•Dizziness (11%)

•Weakness (10%)

•Dry mouth (9%)

•Constipation (9%)

•Upset stomach (7%)

•Runny nose (7%)
Warnings of Latuda vs. Zyprexa
Common Side Effects for

•Worsening depression, suicidal thoughts, and unusual behavior

•Higher risk of death in older adults with dementia-related psychosis

•Neuroleptic malignant syndrome

•Difficulty controlling muscle movements (tardive dyskinesia)

•Changes in weight, blood sugar levels, and cholesterol levels

•High prolactin levels

•Changes in blood pressure and risk of falls

•Risk of infection (from low white blood cell count)

•Difficulty concentrating and extreme sleepiness

•Seizures

•Triggering a manic episode

•Side effects affecting the nervous system in people with Parkinson's disease or Lewy body dementia

Common Side Effects for

•Higher risk of death in older people with dementia-related psychosis

•Worsening depression, suicidal thoughts and behavior

•Severe allergic skin reactions

•Neuroleptic malignant syndrome

•Weight gain, higher blood sugar, and higher cholesterol levels

•Difficulty controlling body movements

•Changes in blood pressure and higher risk of falls

•Risk of infection (from low white blood cell count)

•Seizures

•High prolactin levels

•Difficulty concentrating and extreme sleepiness

•Anticholinergic side effects
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Compare Latuda vs. Zyprexa

Key takeaways

Summary of Latuda vs. Zyprexa

Indications of Latuda vs. Zyprexa

Pros and Cons of Latuda vs. Zyprexa

Common Side Effects of Latuda vs. Zyprexa

Warnings of Latuda vs. Zyprexa

Prices with our coupons for Latuda vs. Zyprexa

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