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Compare Latuda vs. Vraylar

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Latuda (lurasidone) and Vraylar (cariprazine) are both atypical antipsychotics, but they have some key differences. Latuda is used to treat schizophrenia in people aged 13 and older and bipolar depression in people aged 10 and older. Vraylar, on the other hand, is used for schizophrenia, bipolar I disorder, and as an add-on for major depressive disorder (MDD) in adults only. Latuda is available as a generic, while Vraylar is only available as a brand-name medication. Latuda is taken once a day with food, whereas Vraylar can be taken with or without food. Common side effects of Latuda include sleepiness and nausea, while Vraylar often causes uncontrolled muscle movements and headaches. Both medications have a risk of causing weight gain, but this is less common with Vraylar.

drug combination

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  • Latuda (lurasidone)
    Vraylar (cariprazine)
  • Latuda (lurasidone)
    Vraylar (cariprazine)

  • Summary of Latuda vs. Vraylar

    Summary for Atypical antipsychotic
    Prescription only

    Latuda (lurasidone) is an atypical antipsychotic that's used to treat schizophrenia in adults and children age 13 years and older. It can also be used for treating depression from bipolar disorder in adults and children age 10 years and older. Latuda (lurasidone) is a tablet that's taken by mouth once per day. The most common side effect is sleepiness, and the medication is less likely to cause weight gain compared to other antipsychotics.

    Summary for Atypical antipsychotic
    Prescription only

    Vraylar (cariprazine) is an atypical antipsychotic used to treat schizophrenia and bipolar I disorder in adults. It can also be used as an add-on medication to help with major depressive disorder (MDD). Vraylar (cariprazine) is taken by mouth once a day. Some common side effects of this medication include uncontrolled muscle movements, headache, and restlessness. Unlike some other antipsychotic medications, Vraylar (cariprazine) causes minimal weight gain. Vraylar (cariprazine) is brand name only and not available as a generic medication.

  • Indications of Latuda vs. Vraylar

    Indications for
    •Schizophrenia in people age 13 years and older
    •Depression from bipolar disorder in people age 10 years and older
    •Add-on therapy to lithium (Lithobid) or divalproex (Depakote) for depression from bipolar disorder in adults
    Indications for
    •Schizophrenia
    •Manic or mixed episodes of bipolar I disorder
    •Bipolar depression of bipolar I disorder
    •Major depressive disorder (MDD), as an add-on medication

  • Pros and Cons of Latuda vs. Vraylar

    Pros and Const for Atypical antipsychotic
    Pros
    •Works well for depression from bipolar disorder and schizophrenia
    •Only need to take it once a day
    •Can use in adults and children
    •Less likely to affect your weight than other antipsychotics
    Cons
    •Can take several weeks before you feel the full effects
    •Can make you feel sleepy
    •Can cause movement problems
    •Only available as a tablet
    Pros and Const for Atypical antipsychotic
    Pros
    •Taken once a day
    •Can be taken with or without food
    •Works in your body for a longer period of time than other similar medications
    Cons
    •You might have to see your healthcare provider several times until you find a dose that works best for you.
    •Higher risk for uncontrolled muscle movements than some similar medications
    •Might take several weeks before you experience the full effects of this medication

  • Common Side Effects of Latuda vs. Vraylar

    Common Side Effects for
    •Sleepiness
    •Nausea
    •Difficulty moving or slow movements
    •Can't stay still
    Common Side Effects for
    •Uncontrolled muscle movements (up to 20%)
    •Headache (up to 18%)
    •Restlessness (up to 14%)
    •Trouble sleeping (up to 13%)
    •Constipation (up to 10%)
    •Nausea (up to 8%)
    •Stomach pain (up to 7%)
    •Toothache (up to 6%)

  • Warnings of Latuda vs. Vraylar

    Common Side Effects for
    •Worsening depression, suicidal thoughts, and unusual behavior
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Changes in weight, blood sugar levels, and cholesterol levels
    •High prolactin levels
    •Changes in blood pressure and risk of falls
    •Risk of infection (from low white blood cell count)
    •Difficulty concentrating and extreme sleepiness
    •Seizures
    •Triggering a manic episode
    •Side effects affecting the nervous system in people with Parkinson's disease or Lewy body dementia
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Suicidal thoughts and behavior
    •Neuroleptic malignant syndrome
    •High blood sugar, high cholesterol, and weight gain
    •Difficulty controlling movements (tardive dyskinesia)
    •Higher risk of infections
    •Higher risk of falls
    •Trouble controlling body temperature
    •Difficulty swallowing
    •Seizures

  • Prices with our coupons for Latuda vs. Vraylar

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    Learn more about Vraylar

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