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Compare Latuda vs. Abilify

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Latuda (lurasidone) and Abilify (aripiprazole) are both atypical antipsychotics used to treat mental health conditions, but they have some differences. Latuda is used for schizophrenia and bipolar depression, while Abilify treats schizophrenia, bipolar I disorder, depression (as an add-on), Tourette syndrome, and irritability associated with autism. Latuda is taken once daily as a tablet, whereas Abilify is available in multiple forms, including tablets, oral solutions, and orally disintegrating tablets. Latuda is less likely to cause weight gain compared to other antipsychotics, while Abilify has a lower risk of weight gain but can still cause it. Common side effects of Latuda include sleepiness and nausea, while Abilify often causes headaches, agitation, and trouble sleeping. Both medications can cause serious side effects like neuroleptic malignant syndrome and movement problems, but Abilify also has a risk of impulse-control issues.

Latuda (lurasidone)
Aripiprazole (Abilify)
Latuda (lurasidone)
Aripiprazole (Abilify)
Summary of Latuda vs. Abilify
Summary for Atypical antipsychotic
Prescription only
Latuda (lurasidone) is an atypical antipsychotic that's used to treat schizophrenia in adults and children age 13 years and older. It can also be used for treating depression from bipolar disorder in adults and children age 10 years and older. Latuda (lurasidone) is a tablet that's taken by mouth once per day. The most common side effect is sleepiness, and the medication is less likely to cause weight gain compared to other antipsychotics.
Summary for Atypical antipsychotic
Prescription only
Aripiprazole (Abilify) is an atypical antipsychotic used to treat different mental health conditions, such as schizophrenia and bipolar I disorder. It works by balancing certain chemicals in the brain to help control thoughts, mood, and behaviors. It's available in many dosage forms, including an oral tablet, solution, and an orally disintegrating tablet (ODT) that can be used in adults and children as young as 6 years old for certain conditions. Common side effects include headache, movement problems, and sleep problems.
Indications of Latuda vs. Abilify
Indications for

•Schizophrenia in people age 13 years and older

•Depression from bipolar disorder in people age 10 years and older

•Add-on therapy to lithium (Lithobid) or divalproex (Depakote) for depression from bipolar disorder in adults

Indications for

•Schizophrenia

•Tourette syndrome in children

•Bipolar I disorder

•Depression (add-on treatment)

•Irritability associated with autistic disorder in children
Pros and Cons of Latuda vs. Abilify
Pros and Const for Atypical antipsychotic
Pros

•Works well for depression from bipolar disorder and schizophrenia

•Only need to take it once a day

•Can use in adults and children

•Less likely to affect your weight than other antipsychotics

Cons

•Can take several weeks before you feel the full effects

•Can make you feel sleepy

•Can cause movement problems

•Only available as a tablet

Pros and Const for Atypical antipsychotic
Pros

•Only taken once a day

•Available in a liquid and dissolvable tablet for people who have trouble swallowing pills

•Less likely to cause weight gain than most other antipsychotics

•Available as a lower-cost generic

Cons

•Can make you feel restless

•Risk of movement problems that can be permanent

•Can raise blood sugar and cholesterol

•Can take several weeks to see the full effects
Common Side Effects of Latuda vs. Abilify
Common Side Effects for

•Sleepiness

•Nausea

•Difficulty moving or slow movements

•Can't stay still

Common Side Effects for

•Headache (27%)

•Agitation (19%)

•Trouble sleeping (18%)

•Anxiety (17%)

•Nausea (15%)

•Vomiting (11%)

•Constipation (11%)

•Dizziness (10%)

•Trouble staying still (10%)

Note: Side effects were reported by adults who took aripiprazole in clinical studies for schizophrenia and bipolar disorder.
Warnings of Latuda vs. Abilify
Common Side Effects for

•Worsening depression, suicidal thoughts, and unusual behavior

•Higher risk of death in older adults with dementia-related psychosis

•Neuroleptic malignant syndrome

•Difficulty controlling muscle movements (tardive dyskinesia)

•Changes in weight, blood sugar levels, and cholesterol levels

•High prolactin levels

•Changes in blood pressure and risk of falls

•Risk of infection (from low white blood cell count)

•Difficulty concentrating and extreme sleepiness

•Seizures

•Triggering a manic episode

•Side effects affecting the nervous system in people with Parkinson's disease or Lewy body dementia

Common Side Effects for

•Higher risk of death in older adults with dementia-related psychosis

•Neuroleptic malignant syndrome

•High blood sugar, high cholesterol, and weight gain

•Difficulty controlling movements

•Changes in blood pressure and higher risk of falls

•Risk of infection (from low white blood cell count)

•Difficulty concentrating and extreme sleepiness

•Seizures

•Impulse-control problems
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Compare Latuda vs. Abilify

Key takeaways

Summary of Latuda vs. Abilify

Indications of Latuda vs. Abilify

Pros and Cons of Latuda vs. Abilify

Common Side Effects of Latuda vs. Abilify

Warnings of Latuda vs. Abilify

Prices with our coupons for Latuda vs. Abilify

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