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Compare Latuda vs. Rexulti

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Latuda (lurasidone) and Rexulti (brexpiprazole) are both atypical antipsychotics, but they have some key differences. Latuda is used to treat schizophrenia in people aged 13 and older and depression from bipolar disorder in people aged 10 and older. Rexulti, on the other hand, is used for schizophrenia and as an add-on treatment for depression in adults, and it can also treat dementia-related agitation from Alzheimer's disease. Both Latuda and Rexulti are available as brand and generic forms. Latuda is less likely to cause weight gain compared to other antipsychotics, whereas Rexulti can cause moderate weight gain. Common side effects of Latuda include sleepiness and nausea, while Rexulti often causes restlessness and headaches. Both medications can cause serious side effects like neuroleptic malignant syndrome and tardive dyskinesia, but they differ in their specific risk profiles and additional warnings.

Latuda (lurasidone)
Brexpiprazole (Rexulti)
Latuda (lurasidone)
Brexpiprazole (Rexulti)
Summary of Latuda vs. Rexulti
Summary for Atypical antipsychotic
Prescription only
Latuda (lurasidone) is an atypical antipsychotic that's used to treat schizophrenia in adults and children age 13 years and older. It can also be used for treating depression from bipolar disorder in adults and children age 10 years and older. Latuda (lurasidone) is a tablet that's taken by mouth once per day. The most common side effect is sleepiness, and the medication is less likely to cause weight gain compared to other antipsychotics.
Summary for Atypical Antipsychotic
Prescription only
Brexpiprazole (Rexulti) is an atypical antipsychotic medication approved to treat depression (add-on medication) and schizophrenia. Brand name Rexulti can also treat dementia-related agitation from Alzheimer's disease. Brexpiprazole (Rexulti) is taken by mouth, typically once daily. Some of its more common side effects of brexpiprazole (Rexulti) include restlessness, moderate weight gain, and headaches. It's available as a generic medication.
Indications of Latuda vs. Rexulti
Indications for

•Schizophrenia in people age 13 years and older

•Depression from bipolar disorder in people age 10 years and older

•Add-on therapy to lithium (Lithobid) or divalproex (Depakote) for depression from bipolar disorder in adults

Indications for

•Schizophrenia

•Add-on treatment for depression

•Dementia-related agitation from Alzheimer's disease
Pros and Cons of Latuda vs. Rexulti
Pros and Const for Atypical antipsychotic
Pros

•Works well for depression from bipolar disorder and schizophrenia

•Only need to take it once a day

•Can use in adults and children

•Less likely to affect your weight than other antipsychotics

Cons

•Can take several weeks before you feel the full effects

•Can make you feel sleepy

•Can cause movement problems

•Only available as a tablet

Pros and Const for Atypical Antipsychotic
Pros

•Only need to take the medication once a day

•Less likely to cause weight gain, high cholesterol, or high blood sugar compared with other similar medications

•Less likely to cause movement side effects compared to some other antipsychotics

Cons

•Can be expensive because it's only available as a brand-name medication

•Not recommended for use in pregnancy

•Your healthcare provider might need to adjust your dose several times before you find one that works best for you
Common Side Effects of Latuda vs. Rexulti
Common Side Effects for

•Sleepiness

•Nausea

•Difficulty moving or slow movements

•Can't stay still

Common Side Effects for

•Fidgeting (9%)

•Weight gain (7%)

•Headache (7%)

•Sleepiness (5%)

•Tremor (4%)

•Common cold (4%)

•Larger appetite (3%)

•Fatigue (3%)

•Dizziness (3%)

•Restlessness (3%)

•Anxiety (3%)

•Heartburn (3%)

•Diarrhea (3%)

•Constipation (2%)
Warnings of Latuda vs. Rexulti
Common Side Effects for

•Worsening depression, suicidal thoughts, and unusual behavior

•Higher risk of death in older adults with dementia-related psychosis

•Neuroleptic malignant syndrome

•Difficulty controlling muscle movements (tardive dyskinesia)

•Changes in weight, blood sugar levels, and cholesterol levels

•High prolactin levels

•Changes in blood pressure and risk of falls

•Risk of infection (from low white blood cell count)

•Difficulty concentrating and extreme sleepiness

•Seizures

•Triggering a manic episode

•Side effects affecting the nervous system in people with Parkinson's disease or Lewy body dementia

Common Side Effects for

•Higher risk of death in older adults with dementia-related psychosis

•Suicidal thoughts and behavior

•Difficulty controlling muscle movements (tardive dyskinesia)

•Neuroleptic malignant syndrome (NMS)

•High blood sugar, high cholesterol, and weight gain

•Impulsive behavior

•Higher risk of infections

•Higher risk of falls

•Seizures
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Compare Latuda vs. Rexulti

Key takeaways

Summary of Latuda vs. Rexulti

Indications of Latuda vs. Rexulti

Pros and Cons of Latuda vs. Rexulti

Common Side Effects of Latuda vs. Rexulti

Warnings of Latuda vs. Rexulti

Prices with our coupons for Latuda vs. Rexulti

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