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Compare Latuda vs. Invega

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Latuda (lurasidone) and Invega (paliperidone) are both atypical antipsychotics, but they have some key differences. Latuda is used to treat schizophrenia in people aged 13 and older and bipolar depression in people aged 10 and older. Invega, on the other hand, is used for schizophrenia and schizoaffective disorder in adults and adolescents aged 12 and older. Latuda is taken as a tablet once a day with food, while Invega is an extended-release tablet that can be taken with or without food. Latuda is less likely to cause weight gain compared to other antipsychotics, whereas Invega can cause weight gain and higher blood sugar levels. Both medications can cause sleepiness and movement problems, but Latuda is noted for causing sleepiness in up to 17% of users, while Invega can cause abnormal muscle movements in up to 40% of users. Both Latuda and Invega are available in brand and generic forms.

  • Latuda (lurasidone)
    Invega (paliperidone)
  • Latuda (lurasidone)
    Invega (paliperidone)

  • Summary of Latuda vs. Invega

    Summary for Atypical antipsychotic
    Prescription only

    Latuda (lurasidone) is an atypical antipsychotic that's used to treat schizophrenia in adults and children age 13 years and older. It can also be used for treating depression from bipolar disorder in adults and children age 10 years and older. Latuda (lurasidone) is a tablet that's taken by mouth once per day. The most common side effect is sleepiness, and the medication is less likely to cause weight gain compared to other antipsychotics.

    Summary for Atypical antipsychotic
    Prescription only

    Invega (paliperidone) is taken by mouth and used to improve mood, thoughts, and behaviors in people who have schizophrenia or schizoaffective disorder. It's available as both brand and generic versions in an extended-release pill, which means the medication is released slowly in your body. It only needs to be taken once a day. Some common side effects include drowsiness and uncontrolled muscle movements. There are long-acting injection forms of this medication available given by a trained healthcare provider.

  • Indications of Latuda vs. Invega

    Indications for
    •Schizophrenia in people age 13 years and older
    •Depression from bipolar disorder in people age 10 years and older
    •Add-on therapy to lithium (Lithobid) or divalproex (Depakote) for depression from bipolar disorder in adults
    Indications for
    •Schizophrenia
    •Schizoaffective disorder

  • Pros and Cons of Latuda vs. Invega

    Pros and Const for Atypical antipsychotic
    Pros
    •Works well for depression from bipolar disorder and schizophrenia
    •Only need to take it once a day
    •Can use in adults and children
    •Less likely to affect your weight than other antipsychotics
    Cons
    •Can take several weeks before you feel the full effects
    •Can make you feel sleepy
    •Can cause movement problems
    •Only available as a tablet
    Pros and Const for Atypical antipsychotic
    Pros
    •Available in many different strengths to make it easier to customize your dose
    •Can be used in adolescents
    •Only need to take the medication once a day
    Cons
    •You might have to see your provider several times until you find a dose that works best for you
    •Can make you feel sleepy or sedated
    •Can cause weight gain

  • Common Side Effects of Latuda vs. Invega

    Common Side Effects for
    •Sleepiness
    •Nausea
    •Difficulty moving or slow movements
    •Can't stay still
    Common Side Effects for
    •Abnormal muscle movements (up to 40%)
    •Drowsiness (up to 26%)
    •Headache (up to 14%)
    •Irregular heart beat (up to 14%)
    •Vomiting (up to 11%)
    •Anxiety (up to 9%)

  • Warnings of Latuda vs. Invega

    Common Side Effects for
    •Worsening depression, suicidal thoughts, and unusual behavior
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Changes in weight, blood sugar levels, and cholesterol levels
    •High prolactin levels
    •Changes in blood pressure and risk of falls
    •Risk of infection (from low white blood cell count)
    •Difficulty concentrating and extreme sleepiness
    •Seizures
    •Triggering a manic episode
    •Side effects affecting the nervous system in people with Parkinson's disease or Lewy body dementia
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome (NMS)
    •High blood sugar, high cholesterol, and weight gain
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Higher risk of falls
    •High prolactin levels
    •Higher risk of infections
    •Not for people with gut problems
    •Heart rhythm problem (QT prolongation)

  • Prices with our coupons for Latuda vs. Invega

    Learn more about Latuda
    Learn more about Invega

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