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Compare Zyprexa vs. Aristada

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Olanzapine (Zyprexa) and aripiprazole lauroxil (Aristada) are both atypical antipsychotics, but they have some key differences. Olanzapine is available in both oral and injectable forms and is used to treat schizophrenia, bipolar disorder, and certain types of depression when combined with fluoxetine (Prozac). In contrast, aripiprazole lauroxil is only available as a long-acting injection and is used solely for treating schizophrenia. Olanzapine can be taken daily, while aripiprazole lauroxil is administered every 1 to 2 months by a healthcare provider. Olanzapine is available as a lower-cost generic, whereas aripiprazole lauroxil is only available as a brand medication, making it more expensive. Both medications can cause weight gain and high blood sugar, but olanzapine is more likely to cause sleepiness and anticholinergic side effects like dry mouth and constipation. Aripiprazole lauroxil has fewer side effects compared to some other antipsychotics but can cause injection site pain and is not recommended during pregnancy or breastfeeding.

  • Olanzapine (Zyprexa)
    Aristada (aripiprazole lauroxil)
  • Olanzapine (Zyprexa)
    Aristada (aripiprazole lauroxil)

  • Summary of Zyprexa vs. Aristada

    Summary for Atypical antipsychotic
    Prescription only

    Olanzapine (Zyprexa) is an atypical antipsychotic used treat schizophrenia or bipolar disorder. It can also treat depression, in combination with fluoxetine (Prozac), when other treatments haven't worked well. This medication is thought to work by balancing the levels of certain chemicals in the brain. Olanzapine (Zyprexa) is taken by mouth, typically once daily, by adults and children. Olanzapine (Zyprexa) is also available as an injection that's usually given in a hospital or clinic setting. Some of the more common side effects of olanzapine (Zyprexa) include sleep problems, dizziness, and weight gain.

    Summary for Atypical antipsychotic
    Prescription only

    Aristada (aripiprazole lauroxil) is used to improve mood, thoughts, and behaviors in adults who have schizophrenia. It's a long-acting medication that's injected into your muscle every 1 to 2 months by your healthcare provider. It's only used in people who can tolerate Abilify (aripiprazole) oral tablets.

  • Indications of Zyprexa vs. Aristada

    Indications for
    •Schizophrenia in adults and children age 13 years and older
    •Bipolar I disorder in adults and children age 13 years and older

    When taken with fluoxetine (Prozac):

    •Bipolar depression in adults and children age 10 years and older
    •Depression that hasn't responded well to other treatments
    Indications for
    •Schizophrenia

  • Pros and Cons of Zyprexa vs. Aristada

    Pros and Const for Atypical antipsychotic
    Pros
    •Taken by mouth
    •Taken once daily
    •Might notice an improvement in your symptoms in as early as a week of starting olanzapine (Zyprexa)
    •Available as a lower-cost generic
    Cons
    •Can cause anticholinergic side effects, such as constipation and dry mouth
    •Can affect your sleep
    •More likely to cause weight gain, high blood cholesterol, and high blood sugar levels compared to some other atypical antipsychotics
    Pros and Const for Atypical antipsychotic
    Pros
    •Can be given up to once every 2 months
    •Good option for people who have a hard time taking medications by mouth
    •Has fewer side effects compared to some other antipsychotic medications
    •Patient assistance programs are available to help lower the cost
    Cons
    •Can cause high blood sugar and weight gain
    •Must be injected in the muscle at your healthcare provider's office
    •Can cause soreness or pain at the injection site
    •Not recommended for use during pregnancy or breastfeeding
    •Can be expensive because it's only available as a brand medication

  • Common Side Effects of Zyprexa vs. Aristada

    Common Side Effects for
    •Sleepiness (29%)
    •Trouble sleeping (12%)
    •Accidental injury (12%)
    •Dizziness (11%)
    •Weakness (10%)
    •Dry mouth (9%)
    •Constipation (9%)
    •Upset stomach (7%)
    •Runny nose (7%)
    Common Side Effects for
    •Restlessness (11%)
    •Unusual and uncontrollable muscle movements or muscle spasms (5-7%)

  • Warnings of Zyprexa vs. Aristada

    Common Side Effects for
    •Higher risk of death in older people with dementia-related psychosis
    •Worsening depression, suicidal thoughts and behavior
    •Severe allergic skin reactions
    •Neuroleptic malignant syndrome
    •Weight gain, higher blood sugar, and higher cholesterol levels
    •Difficulty controlling body movements
    •Changes in blood pressure and higher risk of falls
    •Risk of infection (from low white blood cell count)
    •Seizures
    •High prolactin levels
    •Difficulty concentrating and extreme sleepiness
    •Anticholinergic side effects
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome (NMS)
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •High blood sugar, high cholesterol, and weight gain
    •Impulsive behavior
    •Higher risk of falls
    •Higher risk of infections
    •Seizures

  • Prices with our coupons for Zyprexa vs. Aristada

    Learn more about Olanzapine
    Learn more about Aristada

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