metoclopramide

Metoclopramide (Reglan) can cause tardive dyskinesia (TD), a side effect in which there is uncontrolled muscle movements in the tongue, face, mouth, lips, hands, arms, legs, and feet. Your risk of this side effect is higher if you take other medications that might also cause TD, such as prochlorperazine or haloperidol (Haldol). Avoid taking metoclopramide (Reglan) if you're taking these medications. Talk to your provider right away if you notice any unusual movements you can't control because they can become permanent.

Metoclopramide (Reglan) can cause other uncontrolled muscle movements in addition to tardive dyskinesia (TD), such as repeated stiffening and twisting of muscles, tremors, jitteriness, pacing, and foot tapping. Symptoms are most commonly seen within the first 6 months and might occur as early as within the first 24 to 48 hours of taking metoclopramide (Reglan). They typically go away after you stop the medication, but some might take 3 months or more to disappear completely. Stop taking the medication and get medical attention right away if you experience these symptoms.

Metoclopramide (Reglan) can cause neuroleptic malignant syndrome (NMS), which is a rare but serious condition that can lead to death. Symptoms include very a high fever, stiff muscles, problems thinking clearly, very fast or uneven heartbeat, and sweating. The risk is higher in people who are also using antipsychotic medications. Stop taking metoclopramide (Reglan) and get medical attention right away if you experience these symptoms. Your provider will let you know later if it's safe for you to restart this medication.

Metoclopramide (Reglan) can cause depression, even in people without a history of depression. Talk to your healthcare provider if you notice any unusual changes in your mood, have suicidal thoughts, or have desires to harm yourself.

Metoclopramide (Reglan) can raise your blood pressure. This is more likely to occur if you’re also taking other medications that raise your blood pressure, such as monoamine oxidase inhibitor (MAOI) antidepressants like isocarboxazid (Marplan). Monitor your blood pressure carefully because a rise might be a symptom of a more serious condition, such as the presence of a certain type of tumor. Talk to your healthcare provider if you notice changes in your blood pressure.

Metoclopramide (Reglan) can raise the level of aldosterone, a hormone that causes water to build up in your body. This leads to swelling in the arms, legs, or around the belly. People who have heart failure or liver problems are more at risk for this swelling. Let your provider know if you notice any swelling in your body or sudden weight gain.