Key takeaways
Invega (paliperidone) and Clozaril (clozapine) are both atypical antipsychotics used to treat schizophrenia, but they have some key differences. Invega is also approved for schizoaffective disorder, while Clozaril is specifically used for schizophrenia that hasn't responded to other treatments and for reducing suicidal behavior in people with schizophrenia or schizoaffective disorder. Invega is available as an extended-release tablet taken once daily, whereas Clozaril requires multiple doses throughout the day. Clozaril has a higher risk of causing low white blood cell counts, requiring regular blood tests under a special monitoring program called REMS. Invega can cause weight gain and drowsiness, but it generally has fewer severe side effects compared to Clozaril, which can also cause serious heart problems and seizures. Both medications can affect your heart rhythm and should be used cautiously if you have heart issues.
