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Compare Invega vs. Rexulti

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Invega (paliperidone) and Rexulti (brexpiprazole) are both atypical antipsychotics, but they have some key differences. Invega is available in both brand and generic forms and is used to treat schizophrenia and schizoaffective disorder. It is taken once daily as an extended-release tablet. Rexulti, also taken once daily, is available only as a brand-name medication and is used to treat schizophrenia, as an add-on for depression, and dementia-related agitation from Alzheimer's disease. Invega can cause side effects like drowsiness and uncontrolled muscle movements, while Rexulti may cause restlessness and moderate weight gain. Additionally, Invega has long-acting injection forms, whereas Rexulti does not. Both medications can cause weight gain, but Rexulti is less likely to cause high cholesterol or high blood sugar compared to other antipsychotics.

  • Invega (paliperidone)
    Brexpiprazole (Rexulti)
  • Invega (paliperidone)
    Brexpiprazole (Rexulti)

  • Summary of Invega vs. Rexulti

    Summary for Atypical antipsychotic
    Prescription only

    Invega (paliperidone) is taken by mouth and used to improve mood, thoughts, and behaviors in people who have schizophrenia or schizoaffective disorder. It's available as both brand and generic versions in an extended-release pill, which means the medication is released slowly in your body. It only needs to be taken once a day. Some common side effects include drowsiness and uncontrolled muscle movements. There are long-acting injection forms of this medication available given by a trained healthcare provider.

    Summary for Atypical Antipsychotic
    Prescription only

    Brexpiprazole (Rexulti) is an atypical antipsychotic medication approved to treat depression (add-on medication) and schizophrenia. Brand name Rexulti can also treat dementia-related agitation from Alzheimer's disease. Brexpiprazole (Rexulti) is taken by mouth, typically once daily. Some of its more common side effects of brexpiprazole (Rexulti) include restlessness, moderate weight gain, and headaches. It's available as a generic medication.

  • Indications of Invega vs. Rexulti

    Indications for
    •Schizophrenia
    •Schizoaffective disorder
    Indications for
    •Schizophrenia
    •Add-on treatment for depression
    •Dementia-related agitation from Alzheimer's disease

  • Pros and Cons of Invega vs. Rexulti

    Pros and Const for Atypical antipsychotic
    Pros
    •Available in many different strengths to make it easier to customize your dose
    •Can be used in adolescents
    •Only need to take the medication once a day
    Cons
    •You might have to see your provider several times until you find a dose that works best for you
    •Can make you feel sleepy or sedated
    •Can cause weight gain
    Pros and Const for Atypical Antipsychotic
    Pros
    •Only need to take the medication once a day
    •Less likely to cause weight gain, high cholesterol, or high blood sugar compared with other similar medications
    •Less likely to cause movement side effects compared to some other antipsychotics
    Cons
    •Can be expensive because it's only available as a brand-name medication
    •Not recommended for use in pregnancy
    •Your healthcare provider might need to adjust your dose several times before you find one that works best for you

  • Common Side Effects of Invega vs. Rexulti

    Common Side Effects for
    •Abnormal muscle movements (up to 40%)
    •Drowsiness (up to 26%)
    •Headache (up to 14%)
    •Irregular heart beat (up to 14%)
    •Vomiting (up to 11%)
    •Anxiety (up to 9%)
    Common Side Effects for
    •Fidgeting (9%)
    •Weight gain (7%)
    •Headache (7%)
    •Sleepiness (5%)
    •Tremor (4%)
    •Common cold (4%)
    •Larger appetite (3%)
    •Fatigue (3%)
    •Dizziness (3%)
    •Restlessness (3%)
    •Anxiety (3%)
    •Heartburn (3%)
    •Diarrhea (3%)
    •Constipation (2%)

  • Warnings of Invega vs. Rexulti

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome (NMS)
    •High blood sugar, high cholesterol, and weight gain
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Higher risk of falls
    •High prolactin levels
    •Higher risk of infections
    •Not for people with gut problems
    •Heart rhythm problem (QT prolongation)
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Suicidal thoughts and behavior
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Neuroleptic malignant syndrome (NMS)
    •High blood sugar, high cholesterol, and weight gain
    •Impulsive behavior
    •Higher risk of infections
    •Higher risk of falls
    •Seizures

  • Prices with our coupons for Invega vs. Rexulti

    Learn more about Invega
    Learn more about Brexpiprazole

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