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Compare Invega vs. Aristada

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Invega (paliperidone) and Aristada (aripiprazole lauroxil) are both atypical antipsychotics used to treat schizophrenia, but they have some key differences. Invega is available in both oral and injectable forms, while Aristada is only available as an injection. Invega can be taken daily as an extended-release pill or injected every 1-6 month depending on the formulation, whereas Aristada is a long-acting injection given every 1 to 2 months. Invega is also approved for schizoaffective disorder, while Aristada is not. Aristada requires you to first tolerate Abilify (aripiprazole) oral tablets before starting the injection, while longer-acting Invega has a similar requirement that patients need to tolerate shorter-acting formulations for a 3-4 months depending on the formulation. Common side effects of Invega include drowsiness and uncontrolled muscle movements, while Aristada can cause restlessness and injection site pain. Both medications can lead to weight gain and high blood sugar, but Aristada is noted for having fewer side effects compared to some other antipsychotics.

  • Invega (paliperidone)
    Aristada (aripiprazole lauroxil)
  • Invega (paliperidone)
    Aristada (aripiprazole lauroxil)

  • Summary of Invega vs. Aristada

    Summary for Atypical antipsychotic
    Prescription only

    Invega (paliperidone) is taken by mouth and used to improve mood, thoughts, and behaviors in people who have schizophrenia or schizoaffective disorder. It's available as both brand and generic versions in an extended-release pill, which means the medication is released slowly in your body. It only needs to be taken once a day. Some common side effects include drowsiness and uncontrolled muscle movements. There are long-acting injection forms of this medication available given by a trained healthcare provider.

    Summary for Atypical antipsychotic
    Prescription only

    Aristada (aripiprazole lauroxil) is used to improve mood, thoughts, and behaviors in adults who have schizophrenia. It's a long-acting medication that's injected into your muscle every 1 to 2 months by your healthcare provider. It's only used in people who can tolerate Abilify (aripiprazole) oral tablets.

  • Indications of Invega vs. Aristada

    Indications for
    •Schizophrenia
    •Schizoaffective disorder
    Indications for
    •Schizophrenia

  • Pros and Cons of Invega vs. Aristada

    Pros and Const for Atypical antipsychotic
    Pros
    •Available in many different strengths to make it easier to customize your dose
    •Can be used in adolescents
    •Only need to take the medication once a day
    Cons
    •You might have to see your provider several times until you find a dose that works best for you
    •Can make you feel sleepy or sedated
    •Can cause weight gain
    Pros and Const for Atypical antipsychotic
    Pros
    •Can be given up to once every 2 months
    •Good option for people who have a hard time taking medications by mouth
    •Has fewer side effects compared to some other antipsychotic medications
    •Patient assistance programs are available to help lower the cost
    Cons
    •Can cause high blood sugar and weight gain
    •Must be injected in the muscle at your healthcare provider's office
    •Can cause soreness or pain at the injection site
    •Not recommended for use during pregnancy or breastfeeding
    •Can be expensive because it's only available as a brand medication

  • Common Side Effects of Invega vs. Aristada

    Common Side Effects for
    •Abnormal muscle movements (up to 40%)
    •Drowsiness (up to 26%)
    •Headache (up to 14%)
    •Irregular heart beat (up to 14%)
    •Vomiting (up to 11%)
    •Anxiety (up to 9%)
    Common Side Effects for
    •Restlessness (11%)
    •Unusual and uncontrollable muscle movements or muscle spasms (5-7%)

  • Warnings of Invega vs. Aristada

    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome (NMS)
    •High blood sugar, high cholesterol, and weight gain
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •Higher risk of falls
    •High prolactin levels
    •Higher risk of infections
    •Not for people with gut problems
    •Heart rhythm problem (QT prolongation)
    Common Side Effects for
    •Higher risk of death in older adults with dementia-related psychosis
    •Neuroleptic malignant syndrome (NMS)
    •Difficulty controlling muscle movements (tardive dyskinesia)
    •High blood sugar, high cholesterol, and weight gain
    •Impulsive behavior
    •Higher risk of falls
    •Higher risk of infections
    •Seizures

  • Prices with our coupons for Invega vs. Aristada

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    Learn more about Aristada

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