Key takeaways
Invega (paliperidone) and Saphris (asenapine) are both atypical antipsychotics, but they have some key differences. Invega (paliperidone) is available in both brand and generic forms and is taken as an extended-release tablet once a day, while Saphris is a dissolvable tablet taken under the tongue twice a day and does not have a generic form. Invega is used to treat schizophrenia and schizoaffective disorder, whereas Saphris is used for schizophrenia and bipolar I disorder. Invega can be used in adolescents for schizophrenia, while Saphris can be used in children aged 10 and older for bipolar disorder. Common side effects of Invega include drowsiness and uncontrolled muscle movements, while Saphris often causes trouble sleeping and mouth numbness. Additionally, Saphris cannot be used in people with severe liver problems, unlike Invega.
