Compare
Foundayo vs. Trulicity

Foundayo (orforglipron) is an oral glucagon-like peptide-1 (GLP-1) receptor agonist. It's approved for weight loss in certain adults. This medication is meant to be used together with a reduced-calorie diet and exercise. Foundayo (orforglipron) comes as tablets and is taken by mouth once a day with or without food. The dose is slowly raised over several weeks. Common side effects include nausea, constipation, and diarrhea.

• Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition

• Nausea (26-35%)
• Constipation (20-27%)
• Diarrhea (21-25%)
• Vomiting (13-24%)
• Indigestion (12-16%)
• Stomach pain (13-14%)
• Headache (8-9%)
• Bloating (7-9%)
• Feeling tired (6-9%)
• Belching (6-8%)
• Gastroesophageal reflux disease (GERD; 6-7%)
• Having a lot of gas (5-6%)
• Hair loss (4-5%)

• Possible risk of thyroid cancer
• Severe stomach side effects
• Kidney damage
• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Low blood sugar
• Allergic reactions
• Eye problems in people with Type 2 diabetes (diabetic retinopathy)
• Lung problems during general anesthesia or deep sedation

Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).

• Manage Type 2 diabetes in people 10 years and older, along with diet and exercise
• Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors

• Nausea (12-21%)
• Diarrhea (7-13%)
• Vomiting (6-13%)
• Stomach pain (7-9%)
• Low appetite (5-9%)
• Fatigue (4-6%)
• Indigestion (3-6%)

• Thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Low blood sugar when used with certain diabetes medications
• Severe allergic reactions
• Kidney damage
• Severe stomach-related side effects
• Worsening eye problems in people with diabetic retinopathy
• Gallbladder problems
• Breathing fluid into your lungs during anesthesia or deep sedation