Trulicity vs. Byetta for Diabetes Type 2 and Management with Incretin-based Therapies: Important Differences and Potential Risks.

Trulicity

(dulaglutide)

Exenatide

Summary for Trulicity

Prescription only

Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps improve blood sugar levels for adults and children with Type 2 diabetes when used along with diet and exercise. It's also approved to lower the risk of heart problems like heart attack, stroke, and heart-related death in certain adults with Type 2 diabetes. The medication comes as a pen that's injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain.

Indications for Trulicity

Type 2 diabetes in people 10 years and older, along with diet and exercise
Lower the risk of heart problems, like heart attack, stroke, or death, in adults with Type 2 diabetes who have heart disease or heart-related risk factors

Pros and Cons for Trulicity

Pros

Works well at lowering A1C
Comes as a ready-to-use injectable pen
Only used once a week
Helps with weight loss

Cons

Commonly causes nausea, vomiting, diarrhea, and stomach pain
Potential risk for thyroid tumors
Can cause problems in the pancreas, kidney, and gallbladder
Not recommended for people with stomach problems

Common Side Effects for Trulicity

Nausea (12-21%)
Diarrhea (7-13%)
Vomiting (6-13%)
Stomach pain (7-9%)
Low appetite (5-9%)
Fatigue (4-6%)
Indigestion (3-6%)

Warnings for Trulicity

Thyroid cancer
Inflammation of the pancreas (pancreatitis)
Low blood sugar when used with certain diabetes medications
Severe allergic reactions
Kidney damage
Severe stomach-related side effects
Worsening eye problems in people with diabetic retinopathy
Gallbladder problems
Breathing fluid into your lungs during anesthesia or deep sedation

Summary for Byetta

Prescription only

Exenatide is a glucagon-like peptide-1 (GLP-1) agonist used along with diet and exercise to help improve blood sugar levels in adults with Type 2 diabetes. It's injected under the skin twice a day before meals, with doses given at least 6 hours apart. Common side effects include nausea, vomiting, and diarrhea. Although the brand names Byetta and Bydureon BCise have been discontinued, a generic version of Byetta is still available.

Indications for Byetta

Type 2 diabetes in adults, along with diet and exercise

Pros and Cons for Byetta

Pros

Helps lower blood sugar after meals
Low risk of low blood sugar when used alone
Might help some people with weight loss

Cons

Must be injected twice a day
Commonly causes nausea and vomiting
Must be used within 60 minutes before meals

Common Side Effects for Byetta

Nausea (up to 44%)
Vomiting (up to 18%)
Diarrhea (up to 18%)
Headache (up to 14%)
Constipation (Up to 10%)

Note: Side effects can vary depending on whether exenatide is taken alone or with other diabetes medications.

Warnings for Byetta

Inflammation of the pancreas (pancreatitis)
Low blood sugar (hypoglycemia) when taken with certain diabetes medications
Kidney problems
Severe stomach problems
Serious allergic reactions
Severe bleeding
Gallbladder problems
Lung problems during anesthesia or deep sedation

Prices with our coupons for Trulicity vs. Byetta

Trulicity1 carton / 4 pens of 0.75mg/0.5ml

$985.69$1,509.99

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Exenatide1 pen / 10mcg

$466.58$892.01

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Trulicity vs. Byetta

Trulicity

Exenatide

Summary for Trulicity

Indications for Trulicity

Pros and Cons for Trulicity

Pros

Cons

Common Side Effects for Trulicity

Warnings for Trulicity

Summary for Byetta

Indications for Byetta

Pros and Cons for Byetta

Pros

Cons

Common Side Effects for Byetta

Warnings for Byetta

Prices with our coupons for Trulicity vs. Byetta

Compare other Diabetes Type 2 and Management with Incretin-based Therapies drugs

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Trulicity

Exenatide

Summary for Trulicity

Indications for Trulicity

Pros and Cons for Trulicity

Pros

Cons

Common Side Effects for Trulicity

Warnings for Trulicity

Summary for Byetta

Indications for Byetta

Pros and Cons for Byetta

Pros

Cons

Common Side Effects for Byetta

Warnings for Byetta