Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Trulicity vs. Tresiba

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Trulicity (dulaglutide)
    Insulin degludec (Tresiba)
  • Trulicity (dulaglutide)
    Insulin degludec (Tresiba)

  • Summary of Trulicity vs. Tresiba

    Summary for GLP-1 agonist
    Prescription only

    Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).

    Summary for Insulin
    Prescription only

    Insulin degludec (Tresiba) is an ultra-long-acting insulin. It's used to manage blood sugar levels in adults and children with Type 1 diabetes or Type 2 diabetes. It's injected under the skin once per day. Insulin degludec (Tresiba) comes as a vial and FlexTouch pen. Side effects include common cold symptoms and headache. Tresiba is available as a brand-name medication and an unbranded biologic.

  • Indications of Trulicity vs. Tresiba

    Indications for
    •Manage Type 2 diabetes in people 10 years and older, along with diet and exercise
    •Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors
    Indications for
    •Type 1 diabetes
    •Type 2 diabetes

  • Pros and Cons of Trulicity vs. Tresiba

    Pros and Const for GLP-1 agonist
    Pros
    •Works well at lowering A1C
    •Comes as a ready-to-use injectable pen
    •Only used once a week
    •Helps with weight loss
    Cons
    •Commonly causes nausea, vomiting, diarrhea, and stomach pain
    •Potential risk for thyroid tumors
    •Can cause problems in the pancreas, kidney, and gallbladder
    •Not recommended for people with stomach problems
    Pros and Const for Insulin
    Pros
    •Injected once daily
    •Each dose can help control blood sugar levels for about 42 hours
    •Can be stored at room temperature for up to 2 months
    Cons
    •Raises risk of dangerously low blood sugar levels
    •Might cause weight gain
    •Can't be mixed with other insulins

  • Common Side Effects of Trulicity vs. Tresiba

    Common Side Effects for
    •Nausea (12-21%)
    •Diarrhea (7-13%)
    •Vomiting (6-13%)
    •Stomach pain (7-9%)
    •Low appetite (5-9%)
    •Fatigue (4-6%)
    •Indigestion (3-6%)
    Common Side Effects for
    •Low blood sugar levels (up to 99%)
    •Common cold (up to 24%)
    •Upper respiratory tract infection (up to 12%)
    •Headache (up to 12%)
    •Diarrhea (up to 6%)
    •Sinus infection (up to 5%)
    •Stomach viral infection (up to 5%)

  • Warnings of Trulicity vs. Tresiba

    Common Side Effects for
    •Thyroid cancer
    •Inflammation of the pancreas (pancreatitis)
    •Low blood sugar when used with certain diabetes medications
    •Severe allergic reactions
    •Kidney damage
    •Severe stomach-related side effects
    •Worsening eye problems in people with diabetic retinopathy
    •Gallbladder problems
    •Breathing fluid into your lungs during anesthesia or deep sedation
    Common Side Effects for
    •Risk of infections with pen sharing
    •Risk of high and low blood sugar levels
    •Dangerously low blood sugar levels (hypoglycemia)
    •Low blood potassium levels
    •Swelling and heart failure when used with certain diabetes medications
    •Allergic reactions

  • Prices with our coupons for Trulicity vs. Tresiba

    Learn more about Trulicity
    Learn more about Insulin degludec

Compare other Diabetes Type 2 drugs

Jardiance vs TrulicityRybelsus vs TrulicityTrulicity vs BydureonTrulicity vs ByettaTrulicity vs JanuviaTrulicity vs MetforminTrulicity vs MounjaroTrulicity vs OzempicTrulicity vs SaxendaTrulicity vs TresibaTrulicity vs WegovyVictoza vs TrulicityZepbound vs TrulicityAdlyxin vs OzempicBydureon vs MounjaroByetta vs OzempicContrave vs MounjaroFarxiga vs OzempicGlyxambi vs OzempicJanuvia vs OzempicJardiance vs MounjaroMetformin vs MounjaroMounjaro vs OzempicPhentermine vs MounjaroQsymia vs MounjaroRybelsus vs MounjaroSaxenda vs MounjaroVictoza vs MounjaroWegovy vs MounjaroZepbound vs Mounjaro
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.