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Trulicity vs. Tresiba

Trulicity (dulaglutide) is a glucagon-like peptide-1 (GLP-1) agonist that helps control blood sugar in people 10 years and older with Type 2 diabetes. It's also approved to lower the risk of heart problems like heart attacks, strokes, and heart-related death in certain adults with Type 2 diabetes. The medication is injected under the skin once a week. Common side effects include nausea, vomiting, diarrhea, and stomach pain. When taken with certain diabetes medications like insulin, there's a higher risk of low blood sugar (hypoglycemia).

• Manage Type 2 diabetes in people 10 years and older, along with diet and exercise
• Lower the risk of heart problems like heart attack, stroke, or death in adults with Type 2 diabetes who have heart disease or heart-related risk factors

• Nausea (12-21%)
• Diarrhea (7-13%)
• Vomiting (6-13%)
• Stomach pain (7-9%)
• Low appetite (5-9%)
• Fatigue (4-6%)
• Indigestion (3-6%)

• Thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Low blood sugar when used with certain diabetes medications
• Severe allergic reactions
• Kidney damage
• Severe stomach-related side effects
• Worsening eye problems in people with diabetic retinopathy
• Gallbladder problems
• Breathing fluid into your lungs during anesthesia or deep sedation

Insulin degludec (Tresiba) is an ultra-long-acting insulin. It's used to manage blood sugar levels in adults and children with Type 1 diabetes or Type 2 diabetes. It's injected under the skin once per day. Insulin degludec (Tresiba) comes as a vial and FlexTouch pen. Side effects include common cold symptoms and headache. Tresiba is available as a brand-name medication and an unbranded biologic.

• Type 1 diabetes
• Type 2 diabetes

• Low blood sugar levels (up to 99%)
• Common cold (up to 24%)
• Upper respiratory tract infection (up to 12%)
• Headache (up to 12%)
• Diarrhea (up to 6%)
• Sinus infection (up to 5%)
• Stomach viral infection (up to 5%)

• Risk of infections with pen sharing
• Risk of high and low blood sugar levels
• Dangerously low blood sugar levels (hypoglycemia)
• Low blood potassium levels
• Swelling and heart failure when used with certain diabetes medications
• Allergic reactions