Key takeaways
Lisinopril (Zestril) and candesartan (Atacand) are both medications used to treat high blood pressure, but they belong to different drug classes. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, while candesartan is an angiotensin II receptor blocker (ARB). Both medications help relax blood vessels, but they do so in different ways. Lisinopril blocks a protein called ACE, whereas candesartan blocks the hormone angiotensin II. Lisinopril is also used to treat heart failure and reduce the risk of death after a heart attack, while candesartan can help lower the risk of worsening heart failure. One notable difference is that Lisinopril is more likely to cause a dry cough, a common side effect of ACE inhibitors. Candesartan is generally well tolerated with few side effects but can cause respiratory tract infections and dizziness. Both medications are available in generic forms, making them more affordable options. Additionally, Lisinopril is available as a liquid, which can be helpful for those who have trouble swallowing tablets, while candesartan can be made into an oral suspension if needed.
