Key takeaways
Felodipine ER (Plendil) and nisoldipine (Sular) are both calcium channel blockers used to treat high blood pressure. Felodipine ER is typically taken once daily in doses ranging from 2.5 mg to 10 mg, while nisoldipine is also taken once daily but in higher doses, starting at 17 mg and going up to 34 mg. Felodipine ER is available only as a generic, whereas nisoldipine is available both as a brand (Sular) and a generic. Common side effects for both medications include swelling, headaches, and dizziness. Felodipine ER can be taken with or without food, but nisoldipine should be taken on an empty stomach. Neither medication should not be crushed or chewed. Felodipine ER can be a first-choice option for treating high blood pressure, while nisoldipine is noted to be more expensive than many other alternatives.
