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Compare Lisinopril vs. Digoxin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Lisinopril (Zestril) and digoxin (Lanoxin) are both prescription medications, but they serve different purposes and belong to different drug classes. Lisinopril is an ACE inhibitor used primarily to lower blood pressure, treat heart failure, and reduce the risk of death after a heart attack. It works by relaxing blood vessels. On the other hand, digoxin is an antiarrhythmic medication used to treat heart failure and atrial fibrillation (AFib) by helping the heart pump more effectively and controlling heart rate. Lisinopril is typically taken once daily and is available in both tablet and liquid forms, while digoxin can be taken once or twice daily, depending on the form and dosage. Common side effects of lisinopril include cough, dizziness, and headache, whereas digoxin can cause vision changes, stomach upset, and dizziness. Additionally, digoxin has a narrow therapeutic index, meaning small changes in dosage can lead to serious side effects, making regular blood tests necessary. Both medications are available in lower-cost generic forms.

  • Lisinopril (Zestril)
    Digoxin (Lanoxin)
  • Lisinopril (Zestril)
    Digoxin (Lanoxin)

  • Summary of Lisinopril vs. Digoxin

    Summary for ACE inhibitor
    Prescription only

    Lisinopril (Zestril) is an angiotensin-converting enzyme (ACE) inhibitor that's a first-choice medication used for lowering blood pressure. It's also approved to treat symptoms of heart failure and also to lower the risk of death after a heart attack. Lisinopril (Zestril) is a tablet that's taken by mouth, typically once daily. It's also available as an oral solution. Some common side effects of this medication include cough, dizziness, and headache.

    Summary for Antiarrhythmic
    Prescription only

    Digoxin (Lanoxin) is an antiarrhythmic medication used to treat heart failure and atrial fibrillation (AFib) in adults and children. It's taken by mouth typically once or twice daily, but the specific dosage will depend on several things like your age, weight, and blood digoxin levels. Side effects include changes in vision, stomach upset, and dizziness. There's also a risk of digoxin toxicity, which means having too much of the medication in your body. This can lead to severe side effects such as vision changes and changes to the heart rhythm.

  • Indications of Lisinopril vs. Digoxin

    Indications for
    •High blood pressure
    •Heart failure
    •Lower the risk for death after a heart attack
    Indications for
    •Heart failure in adults and children ages 5 years and older
    •Atrial fibrillation (AFib) in adults

  • Pros and Cons of Lisinopril vs. Digoxin

    Pros and Const for ACE inhibitor
    Pros
    •A first-choice blood pressure medication
    •Taken by mouth once per day
    •Can be taken by children as young as 6 years old for treatment of high blood pressure
    •Available as a liquid (Qbrelis), good option for people who've difficulty swallowing tablets
    Cons
    •More likely to cause a dry cough, compared to ARBs
    •Can't be taken during pregnancy or breastfeeding
    •Might not work as well for lowering high blood pressure in black people
    Pros and Const for Antiarrhythmic
    Pros
    •Can be used in young children to treat heart failure
    •Doesn't affect blood pressure much
    •Available as a lower-cost generic
    Cons
    •Can cause serious and potentially life-threatening side effects if medication levels in the blood are too high
    •Need to get regular blood tests during treatment
    •Interacts with many medications

  • Common Side Effects of Lisinopril vs. Digoxin

    Common Side Effects for
    •Dizziness (up to 19%)
    •Low blood pressure (7-11%)
    •Higher creatinine levels (7-10%)
    •Headache (6%)
    Common Side Effects for
    •Changes in heart rate
    •Nausea
    •Vomiting
    •Diarrhea
    •Reduced appetite

  • Warnings of Lisinopril vs. Digoxin

    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Worsening kidney problems
    •Heart problems due to high potassium
    •Liver problems
    Common Side Effects for
    •Abnormal heart rhythm
    •Digoxin toxicity
    •Worsening heart conditions
    •Less efficacy in people with low calcium levels
    •Different responses in people with thyroid and metabolism problems

  • Prices with our coupons for Lisinopril vs. Digoxin

    Learn more about Lisinopril
    Learn more about Digoxin

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