Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Candesartan (Atacand) and irbesartan (Avapro) are both angiotensin II receptor blockers (ARBs) used to treat high blood pressure. However, there are some differences between the two. Candesartan is also used to lower the risk of worsening heart failure in adults, while irbesartan is specifically used to slow the worsening of kidney disease from diabetes. Candesartan can be taken once or twice daily, whereas irbesartan is typically taken once daily. Both medications are available in lower-cost generic forms. Common side effects of candesartan include upper respiratory tract infections, dizziness, and back pain, while irbesartan commonly causes dizziness, tiredness, and diarrhea. Both medications should be avoided during pregnancy and can raise potassium levels, but irbesartan is noted to be less effective in controlling blood pressure in Black people.
Irbesartan (Avapro) is a medication that's used to treat high blood pressure; it's also used to treat diabetic kidney disease. It's a part of a drug class called angiotensin II receptor blockers (ARB). The dosage for irbesartan (Avapro) can differ if you've kidney problems or are taking diuretics ("water pills"). Common side effects include dizziness and tiredness. Irbesartan (Avapro) is available in both brand name (Avapro) and generic tablet.
•Can take 4-6 weeks before you notice the full benefit
•Can raise potassium levels as a side effect
Pros and Const for ARB
Pros
•Available as a lower-cost generic medication
•Typically taken once a day
•Less likely to cause dry cough compared to ACE Inhibitors
Cons
•Not safe for use while pregnant
•High risk of raising potassium levels
•Requires regular blood work to make sure your kidneys are healthy
Common Side Effects of Atacand vs. Avapro
Common Side Effects for
•Upper respiratory tract infection (i.e., common cold; 6%)
•Dizziness (4%)
•Back pain (3%)
Common Side Effects for
•Dizziness (up to 10%)
•Low blood pressure when going from sitting to standing position (5%)
•Feeling tired (4%)
•Diarrhea (3%)
•Heartburn (2%)
Please note: People who took irbesartan (Avapro) for high blood pressure were more likely to experience tiredness, diarrhea, and heartburn. People who took this medication for diabetic kidney disease were more likely to experience dizziness.