Key takeaways
Lisinopril (Zestril) and ethacrynic acid (Edecrin) are both prescription medications, but they serve different purposes and belong to different drug classes. Lisinopril is an ACE inhibitor used primarily to lower blood pressure, treat heart failure, and reduce the risk of death after a heart attack. It works by relaxing blood vessels. On the other hand, ethacrynic acid is a loop diuretic, or "water pill," used to reduce swelling (edema) caused by conditions like congestive heart failure, cirrhosis, and kidney problems. It works by removing excess fluid and certain electrolytes from your body. Lisinopril is typically taken once daily and is available in both tablet and liquid forms. Ethacrynic acid can be taken once or twice daily and is available as a tablet and an injection for urgent situations. Common side effects of lisinopril include dizziness and headache, whereas ethacrynic acid can cause dizziness, hearing loss, and electrolyte imbalances. Lisinopril is generally less expensive due to its availability as a generic, while ethacrynic acid is more costly and is often used in people with sulfa allergies who cannot take other diuretics.
