Steglatro (ertugliflozin) is an oral medication that helps lower blood sugar in adults with Type 2 diabetes. It belongs to the drug class called sodium glucose cotransporter 2 (SGLT2) inhibitors. Steglatro (ertugliflozin) is a tablet you take once a day. But it works best when you also follow a balanced diet and regular exercise plan. Common side effects include yeast infections and urinary tract infections. Currently, Steglatro (ertugliflozin) is a brand-name medication only; there's no generic version yet.
Steglatro (ertugliflozin) is a sodium glucose co-transporter 2 inhibitor, or SGLT2 inhibitor for short. It blocks the SGLT2 protein in the kidneys. This stops sugar from absorbing back into your blood and instead makes the sugar go into your urine. This helps get rid of extra sugar in your blood and lower your blood sugar.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Side effects that you should report to your care team as soon as possible:
Steglatro (ertugliflozin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Some people who take SGLT2 inhibitors like Steglatro (ertugliflozin) have had ketoacidosis. This happens when your body makes too many ketones for energy. When there are too many ketones, your blood becomes too acidic, which can be dangerous. Your risk is higher if you're sick, not eating much, drinking a lot of alcohol, or just had surgery.
If you have signs of ketoacidosis, stop taking Steglatro (ertugliflozin) and get medical help right away. Look for signs of severe dehydration (like feeling very thirsty or having a very dry mouth). Other signs include nausea, vomiting, stomach pain, tiredness, and shortness of breath.
Steglatro (ertugliflozin) can cause your body to lose too much fluid. This can lead to low blood pressure. If you feel dizzy, lightheaded, or tired, sit or lie down and tell your care team. These can be signs of having low blood pressure.
Losing too much fluid while taking Steglatro (ertugliflozin) can also cause sudden kidney problems in some people. Your prescriber might check your kidneys with blood tests before and during treatment. This helps make sure your kidneys are okay. Call your care team right away if you're not urinating as much, have swelling in the legs, or feel short of breath. These could be signs of kidney problems.
Steglatro (ertugliflozin) can make you more likely to get urinary tract infections (UTIs). It can also make you more likely to get a genital infection like a yeast infection. And rarely, some people have gotten a very serious and dangerous infection in the genital area called Fournier's gangrene.
Get help from a healthcare professional if you have a fever, pain or burning when you urinate, need to urinate often, or see blood in your urine. These could be signs of a UTI. Also call a healthcare professional if you think you have a genital infection. Watch for signs like fever and itching, pain, soreness, redness, or swelling in that area. You might need to stop taking Steglatro (ertugliflozin) so your care team can help treat the problem.
Although rare, Steglatro (ertugliflozin) might raise some people's risk of needing an amputation in the lower legs. In studies, this was most commonly a toe or foot. People were more likely to have had a higher A1C from the start, an amputation in the past, or diabetic foot ulcer. The most common reasons for amputation were leg infections and foot ulcers.
Pay extra attention to your legs and feet while taking Steglatro (ertugliflozin). Also, remember to visit your care team regularly for foot exams.
Tell your care team if you have any new pain, tenderness, sores, infections, or ulcers on your legs or feet. If this happens, you might need to stop taking Steglatro (ertugliflozin). Your care team can help you manage these foot problems or treat them before they get worse.
Your blood sugar can go too low if you take [[EDITOR|DRUG_DISPLAY_NAMEe]] with certain diabetes medications. Insulin is a common example. But a few other ones include sulfonylureas like glipizide and glinides like repaglinide. Your prescriber might lower the dose of these medications to prevent your blood sugar from going too low.
Still, make sure you know how to tell if your blood sugar is low. Watch for signs like feeling hungry, shaky, irritated, weak, dizzy, or confused. You might also sweat a lot or have a fast heartbeat. Take fast-acting sugars to get your sugars back up and let your prescriber know.
| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 5mg | 30 tablets | $350.19 | $11.67 |
| 15mg | 30 tablets | $350.19 | $11.67 |
The typical starting dose is 5 mg by mouth once daily in the morning, with or without food.
Your prescriber might raise your dose depending on how you respond to the medication. The maximum dose is 15 mg once daily.
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As of summer 2025, there isn't a generic for Steglatro. It's currently only available as a brand-name medication.
It can take several weeks or a few months of taking Steglatro before you see a change in your A1C. Your A1C measures your average blood sugar levels over a few months. If you've been taking the medication for several months and your A1C hasn't improved, talk to your diabetes care team. They can help adjust your diabetes treatment plan.
Most of Steglatro leaves your system about 3 to 4 days after a single dose. This estimate is based on the medication's half-life. This is a measure of how long it takes for the initial amount of medication in the body to drop by half. If you have kidney problems, Steglatro might stay in your system a bit longer since your kidneys can't get rid of it as well. Ask your prescriber if you have specific questions.
No. Don't take Steglatro and Jardiance (empagliflozin) together. These medications belong to the same drug class called SGLT2 inhibitors. They work in the same way to lower your blood sugar. Taking them together won't help you more. In fact, it could raise your risk of side effects like yeast infections and urinary tract infections. Talk to your care team to learn which diabetes medications you can take together.
Some people might lose weight while taking Steglatro. In studies, people who took the medication for 6 months lost an average of almost 7 lbs. This amount of weight loss was pretty stable when people took the medication for a year. It's best to take Steglatro along with a balanced diet and regular exercise. This will help manage both your diabetes and your weight. Remember that Steglatro isn't approved just for weight loss. Talk to your care team about how to manage your weight appropriately.
It's possible you might feel dizzy while taking Steglatro. This medication can make your body lose water, which can make your blood pressure drop. When your blood pressure is low, you can feel dizzy. Drink plenty of fluids while taking Steglatro. It lowers the chance of this happening. If you feel dizzy, be sure to sit or lie down until you feel better. Let your care team know if this happens.
Erectile dysfunction (ED) isn't a common side effect of Steglatro. But remember that diabetes can often cause ED. If your sugar levels are too high for a long time, it can damage the blood vessels and nerves that help with sexual function. If you're having trouble getting or keeping an erection, talk to your primary care provider.
No, Steglatro and Farxiga (dapagliflozin) aren't the same. They're both oral Type 2 diabetes medications that are taken once a day. And they work in the same way to lower blood sugar. But there are a few differences. First, Steglatro is only for adults whereas Farxiga is for people over age 10 with Type 2 diabetes. And, Farxiga has some approved benefits that Steglatro doesn't have. Farxiga is also approved to help keep adults with Type 2 diabetes and heart failure out of the hospital for their heart problem. It can also slow kidney problems in people with chronic kidney disease. Talk to your diabetes care team about how these medications compare and which is right for you.