Key takeaways
Enalapril (Vasotec, Epaned) and lisinopril (Zestril, Qbrelis) are both medications in the angiotensin-converting enzyme (ACE) inhibitor class, used to treat high blood pressure and heart failure. However, there are notable differences between them. Enalapril is available in both tablet and liquid forms and can be taken by children as young as 1 month old for high blood pressure, while lisinopril is available as a tablet and liquid but is only approved for children 6 years and older. Lisinopril has an additional FDA-approved indication to lower the risk of death after a heart attack, which enalapril does not have. Enalapril is typically taken once or twice daily, whereas lisinopril is usually taken once daily. Both medications can cause a dry cough, dizziness, and feeling tired as possible side effects. Both medications are available as lower-cost generics. Both medications can interact with non-steroidal anti-inflammatory drugs (NSAIDs) and should not be used during pregnancy.
