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Compare Vasotec vs. Zestril

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Enalapril (Vasotec, Epaned) and lisinopril (Zestril, Qbrelis) are both angiotensin-converting enzyme (ACE inhibitors) used to treat high blood pressure and heart failure. They work by relaxing blood vessels, which helps lower blood pressure. However, lisinopril is also FDA-approved to lower the risk of death after a heart attack, but enalapril is not. Enalapril can be taken by children as young as 1 month old, while lisinopril is only approved for children 6 years and older. Enalapril is typically taken once or twice daily, whereas lisinopril is usually taken once daily. Both medications can cause a dry cough, dizziness, and feeling tired as possible side effects. Both enalapril and lisinopril are available as oral tablets and oral liquid. Both medications can interact with nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Motrin, Advil), which can increase the risk of kidney problems. Both are available as lower-cost generics.

  • Enalapril (Vasotec)
    Lisinopril (Zestril)
  • Enalapril (Vasotec)
    Lisinopril (Zestril)

  • Summary of Vasotec vs. Zestril

    Summary for ACE inhibitor
    Prescription only

    Enalapril (Vasotec) is a first-choice medication used for treating high blood pressure. It's also approved for heart failure. Enalapril (Vasotec) belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It's taken by mouth, once or twice daily. Enalapril (Vasotec) doesn't cause many side effects, but some include tiredness, dizziness, and cough.

    Summary for ACE inhibitor
    Prescription only

    Lisinopril (Zestril) is an angiotensin-converting enzyme (ACE) inhibitor that's a first-choice medication used for lowering blood pressure. It's also approved to treat symptoms of heart failure and also to lower the risk of death after a heart attack. Lisinopril (Zestril) is a tablet that's taken by mouth, typically once daily. It's also available as an oral solution. Some common side effects of this medication include cough, dizziness, and headache.

  • Indications of Vasotec vs. Zestril

    Indications for
    •High blood pressure
    •Heart failure
    Indications for
    •High blood pressure
    •Heart failure
    •Lower the risk for death after a heart attack

  • Pros and Cons of Vasotec vs. Zestril

    Pros and Const for ACE inhibitor
    Pros
    •A first-choice blood pressure lowering medication for many people
    •Taken by mouth
    •Can be taken by children as young as 1 month old (high blood pressure only)
    •Available as a liquid for people who have trouble swallowing pills
    Cons
    •More likely to cause a dry cough, compared to angiotensin II receptor blockers (ARBs)
    •Can't be taken during pregnancy or breastfeeding
    •Might not work as well for lowering high blood pressure in black people
    •Need to take twice daily for heart failure
    Pros and Const for ACE inhibitor
    Pros
    •A first-choice blood pressure medication
    •Taken by mouth once per day
    •Can be taken by children as young as 6 years old for treatment of high blood pressure
    •Available as a liquid (Qbrelis), good option for people who've difficulty swallowing tablets
    Cons
    •More likely to cause a dry cough, compared to ARBs
    •Can't be taken during pregnancy or breastfeeding
    •Might not work as well for lowering high blood pressure in black people

  • Common Side Effects of Vasotec vs. Zestril

    Common Side Effects for
    •Feeling tired (3%)
    Common Side Effects for
    •Dizziness (up to 19%)
    •Low blood pressure (7-11%)
    •Higher creatinine levels (7-10%)
    •Headache (6%)

  • Warnings of Vasotec vs. Zestril

    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Worsening kidney problems
    •Heart problems due to high potassium
    •Liver problems
    Common Side Effects for
    •Not for use during pregnancy
    •Angioedema (swelling)
    •Low blood pressure
    •Worsening kidney problems
    •Heart problems due to high potassium
    •Liver problems

  • Prices with our coupons for Vasotec vs. Zestril

    Learn more about Enalapril
    Learn more about Lisinopril

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