Key takeaways
Enalapril (Vasotec, Epaned) and lisinopril (Zestril, Qbrelis) are both angiotensin-converting enzyme (ACE inhibitors) used to treat high blood pressure and heart failure. They work by relaxing blood vessels, which helps lower blood pressure. However, lisinopril is also FDA-approved to lower the risk of death after a heart attack, but enalapril is not. Enalapril can be taken by children as young as 1 month old, while lisinopril is only approved for children 6 years and older. Enalapril is typically taken once or twice daily, whereas lisinopril is usually taken once daily. Both medications can cause a dry cough, dizziness, and feeling tired as possible side effects. Both enalapril and lisinopril are available as oral tablets and oral liquid. Both medications can interact with nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Motrin, Advil), which can increase the risk of kidney problems. Both are available as lower-cost generics.
