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Compare Zestril vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Lisinopril (Zestril)
Zestoretic (lisinopril / hydrochlorothiazide)
Lisinopril (Zestril)
Zestoretic (lisinopril / hydrochlorothiazide)

Summary of Zestril vs. Zestoretic

Summary for ACE inhibitor
Prescription only

Lisinopril (Zestril) is an angiotensin-converting enzyme (ACE) inhibitor that's a first-choice medication used for lowering blood pressure. It's also approved to treat symptoms of heart failure and also to lower the risk of death after a heart attack. Lisinopril (Zestril) is a tablet that's taken by mouth, typically once daily. It's also available as an oral solution. Some common side effects of this medication include cough, dizziness, and headache.

Summary for ACE inhibitor/Diuretic (water pill) combo
Prescription only

Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

Indications of Zestril vs. Zestoretic

Indications for
•High blood pressure
•Heart failure
•Lower the risk for death after a heart attack
Indications for
•High blood pressure in adults

Pros and Cons of Zestril vs. Zestoretic

Pros and Const for ACE inhibitor
Pros
•A first-choice blood pressure medication
•Taken by mouth once per day
•Can be taken by children as young as 6 years old for treatment of high blood pressure
•Available as a liquid (Qbrelis), good option for people who've difficulty swallowing tablets
Cons
•More likely to cause a dry cough, compared to ARBs
•Can't be taken during pregnancy or breastfeeding
•Might not work as well for lowering high blood pressure in black people
Pros and Const for ACE inhibitor/Diuretic (water pill) combo
Pros
•Combines two medications in one pill
•Taken by mouth
•Taken once daily
Cons
•Can make you urinate more often
•Might not be appropriate for someone with a sulfa allergy
•Shouldn't take during pregnancy or breastfeeding

Common Side Effects of Zestril vs. Zestoretic

Common Side Effects for
•Dizziness (up to 19%)
•Low blood pressure (7-11%)
•Higher creatinine levels (7-10%)
•Headache (6%)
Common Side Effects for
•Dizziness (8%)
•Headache (5%)
•Cough (4%)
•Extreme tiredness (4%)
•Feeling lightheaded when standing after sitting or lying down (3%)

Warnings of Zestril vs. Zestoretic

Common Side Effects for
•Not for use during pregnancy
•Angioedema (swelling)
•Low blood pressure
•Worsening kidney problems
•Heart problems due to high potassium
•Liver problems
Common Side Effects for
•Not for use during pregnancy
•Angioedema (swelling)
•Low blood pressure
•Kidney damage
•Changes in electrolyte, blood sugar, and cholesterol levels
•Vision problems
•Lupus

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